Nanoparticle coupling significantly enhance the immune response of VOVID-19 vaccines
Nanoparticle coupling significantly enhance the immune response of VOVID-19 vaccines. China News Service, Guangzhou, November 27 (Xu Qingqing and Wu Lijian) Sun Yat-sen University (China) announced on the evening of the 26th that the top international immunology journal “Immunity” published on November 25, Pacific Time, developed by Professor Zhang Hui’s research group from the Institute of Human Virology, Sun Yat-sen University The results of a new nanoparticle vaccine against the new coronavirus. The research team found that nanoparticle coupling can significantly enhance the protective immune response of protein vaccines. Currently, this nanoparticle vaccine is applying for clinical approval to the State Food and Drug Administration.
The article stated that the neutralizing antibody titer against the new coronavirus induced by this nanoparticle vaccine in mice ranked first in the world, and the neutralizing antibody titer induced in rhesus monkeys ranked third in the world. Although each laboratory has different detection methods and experimental sensitivity, it can still reflect the high titer of the nanoparticle vaccine.
Zhang Hui introduced that unlike inactivated vaccines, attenuated vaccines and adenovirus vaccines with mature technical routes, the nanoparticle vaccine is a multi-antigen recombinant protein vaccine, which can display 24 identical or Different new coronavirus antigens.
Zhang Hui’s team performed a wild-type SARS-CoV-2 respiratory tract infection on a humanized mouse model immunized with the nanoparticle vaccine. It was found that the lungs of the unimmunized mice were severely damaged, the virus replicated rapidly, and some mice They died three days after infection. The mice immunized with the nanoparticle vaccine are in good health, with no lung damage, and no residual virus can be detected in 11 organs and tissues including the lung. It can be seen that the neutralizing antibodies induced by the nanoparticle vaccine can significantly protect the body from the new coronavirus infection.
In terms of safety, the experimental results showed that the nanoparticle vaccine did not cause side effects such as damage to other organs in mice. The team also tested whether the antibodies induced by the mice might cause antibody-dependent infection enhancement (ADE). None of the antibodies induced by the particle vaccine has an ADE effect