November 27, 2022

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Can fatty liver be treated with lowering blood lipids?

Can fatty liver be treated with lowering blood lipids?



 

 

Can fatty liver be treated with lowering blood lipids?

Fatty liver is a very common metabolic disease, and its prevalence accounts for about 25% of the total population. Patients with metabolic fatty liver disease are closely related to diseases such as hypertension, hyperlipidemia, diabetes, obesity, and atherosclerosis.

 

Fatty liver is a very common metabolic disease, and its prevalence accounts for about 25% of the total population. Patients with metabolic fatty liver disease are closely related to diseases such as hypertension, hyperlipidemia, diabetes, obesity, and atherosclerosis.

 

Some patients believe that since fatty liver is a disease in which excessive lipids are deposited in the liver, they should be treated with lipid-lowering drugs.

 

So, can patients with metabolic fatty liver disease use lipid-lowering drugs? Will the use of lipid-lowering drugs aggravate liver damage? How to use lipid-lowering drugs?

 

 

 

01 Mainly to control weight and reduce waist circumference

Fatty liver is a metabolic disease, which is closely related to obesity. The so-called “one obesity produces all diseases”, obesity can induce diabetes, cardiovascular and cerebrovascular diseases, and fatty liver.

 

Therefore, maintain a normal body weight and waist circumference to avoid excessive accumu

lation of fat, especially waist circumference reflects the content of visceral fat, and thicker waist circumference represents visceral obesity. In this case, weight loss and waist circumference are the first choices.

Facts have proved that weight loss can not only prevent insulin resistance, metabolic syndrome and cardiovascular and cerebrovascular events, but also effectively prevent obesity-related liver diseases. Scientific weight loss can improve the efficacy of hepatoprotective drugs.

If patients with obese fatty liver reduce their basic weight by more than 5% within half a year, the fat deposits in the liver can be completely subsided, the enlarged liver can be retracted, and liver function can also return to normal .

 

 

 

02 You can use lipid-lowering drugs, but there are requirements

For patients with fatty liver, after three to six months of treatment with lifestyle changes, the patient’s serum low-density lipoprotein cholesterol (LDL-C) is still higher than 4.14 mmol/L, and statins can be used to regulate blood lipid content , Can reduce the serum LDL-C by 30%-40%, so that the cardiovascular system can achieve maximum benefit.

 

Although statins can not effectively reduce the serum transaminase level of patients with fatty liver, nor can they reduce the fat content of the liver, the use of statins can reduce the occurrence of cardiovascular events and reduce the risk of liver cancer and colon cancer in patients with diabetes.

Statins can be safely used in the treatment of patients with metabolic fatty liver disease with dyslipidemia and various types of liver cirrhosis.

 

 

 

03 Monitor liver function with hypolipidemic drugs

Although statins can be used in patients with metabolic fatty liver disease, statins have certain hepatotoxicity and increase transaminase.

Therefore, in the process of using statins to lower blood lipids, if the serum alanine aminotransferase (ALT) is more than 5 times higher than the upper limit of normal, or more than 3 times higher than the upper limit of normal, those with elevated total bilirubin, Stop the medication in time, observe closely, and take liver-protecting anti-inflammatory drugs.

During statin treatment, if muscle discomfort, weakness, or brown urine occurs, serum creatine kinase should be tested in time. If serum creatine kinase is more than 5 times higher than the upper limit of normal, or rhabdomyolysis is suspected, the drug should be stopped immediately.

 

The author believes that when patients with metabolic fatty liver disease are treated with statins, liver function should be closely monitored on the one hand, and liver protection drugs should be taken at the same time, such as polyene phosphatidylcholine, silymarin, bicyclic alcohol, and vitamins. E. Ursodeoxycholic acid, lecithin, etc., choose one or two of them for oral administration, not too much, as far as possible to maintain the normal level of transaminase.

 

 

In addition, n-3 fatty acids (deep sea fish oil), fibrates, etc. can effectively reduce the serum triglyceride levels of patients with metabolic fatty liver disease, mainly used for hypertriglyceridemia, or elevated triglycerides as The main treatment of mixed hyperlipidemia. However, these drugs have little effect on the treatment of fatty liver itself.

 

 

 

(sourceinternet, reference only)


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