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Diabetes are expected to be cured by Stem Cell therapy
Diabetes are expected to be cured by Stem Cell therapy. Stem cells are primitive undifferentiated cells with multidirectional differentiation potential and self-replication ability. The most widely used type of regenerative medicine is mesenchymal stem cells, or MSCs for short.
Nowadays, society is developing rapidly, living conditions are getting better and better, and people’s lifestyles are also changing accordingly. Food and clothing has become a matter of another century, but when our daily dietary intake of calories is getting higher and higher, work and life The number of more and more irregular patients suffering from various “prosperity diseases” is increasing year by year!
Can I get diabetes if I eat too much sugar?
Normally, the human body converts the starchy food it eats into glucose, which serves as the body’s fuel. Insulin is a hormone produced by the pancreas, which allows glucose to enter the cells and provide heat. Diabetes refers to the inability of the pancreas in the human body to produce enough insulin, causing glucose to not fully enter the cells, and the blood sugar concentration will rise to form diabetes.
Eating sugar has no effect on the body itself, but the effect of eating without exercise is increased several times. The amount of blood sugar we need in the body must be constantly balanced and available. When the body cannot effectively use sugar, diabetes occurs.
Among them, insulin, which is responsible for transportation, has a very critical role, because it is the only biologically active substance in the human body that can lower blood sugar and promote blood sugar utilization. When its work exceeds the load, there will be problems with the metabolic level, resulting in Too much sugar in the body cannot be metabolized, and diabetes occurs. Therefore, most diabetics have problems with insulin.
There are two situations after insulin problems:
One is insufficient secretion,
One is insufficient function.
However, the situation is different, there are two types of diabetes:
Type 1 diabetes: mostly occurs in children and adolescents, but can also occur at all ages. The onset is relatively rapid, the body’s insulin is absolutely insufficient, and ketoacidosis is prone to occur. It must be treated with insulin to obtain a satisfactory effect, otherwise it will be life-threatening. A more common situation is that antibodies against pancreatic β cells are produced in the body. Due to the attack of these antibodies, the pancreatic β cells cannot effectively secrete insulin.
The symptoms of type 1 diabetes are: the onset is generally rapid, with thirst, polydipsia, polyuria, polyphagia, fatigue, weight loss, and other symptoms are very obvious. Some patients have ketoacidosis at the first episode. This disease usually occurs in childhood or adolescence, and can also occur at all ages throughout the life, especially menopause.
Type 2 diabetes: The ability to produce insulin in the patient’s body is not completely lost. Some patients even produce too much insulin in the body, but the effect of insulin is poor. Therefore, the patient’s insulin is relatively lacking and can be stimulated by certain oral drugs The secretion of insulin in the body.
Symptoms of Type 2 Diabetes: Some patients are mainly insulin resistant. The patients are obese. Due to insulin resistance, insulin sensitivity decreases, and blood insulin increases to compensate for their insulin resistance. However, compared with patients with hyperglycemia, insulin secretion is still relatively insufficient . The early symptoms of such patients are not obvious, only mild fatigue and thirst, and macrovascular and microvascular complications can often occur before the diagnosis is clear. Diet therapy and oral hypoglycemic drugs can be effective. Another part of patients is mainly due to insulin secretion defects and needs to be supplemented with exogenous insulin clinically.
Stem cell therapy:
At present, these mainstream treatment methods are mainly to control the blood sugar level. What can be done to save β cells is still limited, and the road to completely cure diabetes is still far away.
Stem cell transplant
Stem cell treatment of diabetes brings new opportunities
Stem cells are primitive undifferentiated cells with multidirectional differentiation potential and self-replication ability. The most widely used type of regenerative medicine is mesenchymal stem cells, or MSCs for short.
The repair and regeneration of damaged tissues and organs with multidirectional differentiation potential, self-renewal and secretion of multiple factors are widely used in treatment. A large number of trials and clinical findings have found that mesenchymal stem cells can differentiate into islets in vivo or under specific induction conditions β cells also promote the transformation of macrophages from M1 to M2, thereby improving insulin resistance and promoting islet regeneration. With the improvement of blood sugar, the number of islets and β is regenerated.
The secretion effect of stem cells improves the damage environment and promotes the damage of a cells and islets. b cell transformation to achieve the purpose of repairing damaged islets
(sourceinternet, reference only)