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- A new generation of virus-free CAR-T cell therapy
How about the current situation after 1st child cured by CAR-T in 2012?
How about the current situation after 1st child cured by CAR-T in 2012? Even if the tumor shrinks or disappears after a period of treatment, we still dare not say a cure, because the tumor still has the risk of recurrence.
In the treatment of cancer, whether it is an oncologist or a tumor patient, “cure” is not a word that can be easily uttered. Even if the tumor shrinks or disappears after a period of treatment, we still dare not say a cure, because the tumor still has the risk of recurrence.
Therefore, only after a period of time to verify that the tumor has not recurred, people will think that the patient has reached the point of recovery, and this time is generally 5 years-after a large amount of clinical data verification, the vast majority of cancers will relapse Recurrence within 5 years, if the tumor patient has passed the 5-year threshold, it often means that the probability of recurrence is small, and it also means that the tumor patient has achieved a “cured” result.
So, since participating in the clinical trial of CAR-T cell therapy that was not yet appoved in 2012, how is the last cured child Emily?
In April 2012, Emily, who was only 6 years old at the time, was diagnosed with acute lymphoblastic leukemia and had relapsed twice after a variety of treatments. Basically, according to the previous treatment experience, Emily may only have a few months to live.
But her parents did not give up the opportunity to continue treatment. They began to look for new treatments. Finally, they came to the Philadelphia Children’s Hospital. Emily also joined the CAR-T therapy phase I clinical trial at that time. Then there is the familiar story-Emily survived miraculously after receiving treatment, and no tumor cells were detected in the body after treatment, becoming the first child with leukemia to receive cellular immunotherapy.
So, 9 years later, how is Emily now?
Just recently, Emily, just like the usual 8 years, posted a picture of herself-Emily stood in the sun, holding up the familiar sign in her hand, which read: 9 years cancer free!
Emily’s photos taken during the 9th anniversary of the sun (pictures are from the Internet, if there is any infringement, please contact to delete)
Until recently, Emily has become a banner of CAR-T cell therapy. Her deeds have inspired countless people. It was also the fifth year after Emily received treatment, that is, in 2017, the first CAR-T cell therapy was approved. On the market, 2017 was also called the “first year of CAR-T cell therapy”.
In fact, since the first CAR-T cell therapy was launched in 2017, CAR-T cell therapy has entered the fast lane. Up to now, the keywords “Cancer” and “CAR-T” have been searched in clinical trial centers around the world, and nearly a thousand clinical trials have been carried out. The largest number of clinical trial projects are in China and the United States. In fact, China’s ongoing CAR-T cell therapy clinical trial projects have surpassed those of the United States.
CAR-T cell therapy clinical projects being carried out worldwide
(Image source: Clinicaltrials official website)
(sourceinternet, reference only)