December 7, 2022

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Anti-aging: First clinical trial of the effect of NMN on human metabolism

Anti-aging: First clinical trial of the effect of NMN on human metabolism

 

Anti-aging: First clinical trial of the effect of NMN on human metabolism.  A natural compound that was previously proven to resist aging and improve the metabolic health of mice has achieved similar effects in humans.

A recent new study pointed out that a natural compound that was previously proven to resist aging and improve the metabolic health of mice has achieved similar effects in humans.


A small clinical trial in postmenopausal women with prediabetes showed that the compound NMN (nicotinamide mononucleotide) can increase the ability of insulin to increase glucose uptake in skeletal muscle, which is usually abnormal in obese, prediabetic or type 2 diabetes patients .

And NMN also improves the expression of genes related to muscle structure and remodeling. However, this treatment did not lower blood sugar or blood pressure, improve blood lipid levels, increase liver sensitivity to insulin, and reduce liver fat or inflammation indicators.

This study was published online on April 22 in the journal Science and is the first randomized clinical trial to study the effects of NMN on human metabolism.

In the study, 13 middle-aged, obese, and menopausal women, like most NMN consumers, added two 125mg NMN capsules to their daily breakfast. After insisting on taking it for 10 weeks, the researchers conducted a detailed examination of the participants’ physiological status.

Samuel Klein, professor of medical and nutritional sciences, said: “Usually, when a therapy improves the insulin sensitivity of skeletal muscle, there are related improvements in other metabolic health indicators that we did not find among the study participants.”

Anti-aging: First clinical trial of the effect of NMN on human metabolism

 

The remarkable effect of NMN on rodents has led many companies in Japan, China and the United States to market this compound as a dietary supplement or nutraceutical.

The US FDA does not have the authority to review the safety and effectiveness of food supplement products before they are placed on the market. Therefore, despite the lack of evidence to show that this has clinical benefits, many people in the United States and around the world still take NMN.

Researchers studied 25 postmenopausal women with diabetes, which means that their blood sugar levels are higher than normal, but the levels are not enough to be diagnosed with diabetes. Since mouse studies have shown that NMN has the greatest impact on female mice, women were included in the trial.

What is even more surprising is that after taking NMN, the insulin sensitivity in the muscles of the participants, which is severely reduced by aging, has been improved by up to 25%. This kind of effect has never been achieved by NAD+ supplements such as NR. Obviously, NMN has a unique principle of action that has not yet been proven.

This is only a small-scale clinical trial for unhealthy people, but it is enough to show that anti-aging research has developed to a critical point, and is changing from a subject about flies and mice to a subject about people.



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(source:internet, reference only)


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