German reseachers claim to reveal the thrombosis caused by COVID-19 vaccines
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German reseachers claim to reveal the thrombosis caused by COVID-19 vaccines
German reseachers claim to reveal the thrombosis caused by COVID-19 vaccines. A paper published by German scientists on Wednesday (May 26) stated that they have solved the cause of the rare blood clot associated with the British AstraZeneca-Oxford COVID-19 vaccine.
The British AstraZeneca-Oxford COVID-19 vaccine and the US Johnson & Johnson COVID-19 vaccine, both of which are both adenovirus vector vaccines, had previously experienced cases of rare thrombosis after vaccination, so they were stopped by many countries. Recently, a study by German scientists found the possible causes and possible solutions for the thrombosis problem.
According to the British “Financial Times” report, Professor Rolf Marschalek of the University of Frankfurt, Germany and his team published a preprinted paper (not yet peer-reviewed) on May 26 to discuss the above issues. Studies have shown that the thrombosis problem lies in the adenovirus vector used in the two vaccines. This vector sends some genetic material of the new coronavirus into the nucleus of human cells to produce related proteins, but some mutant proteins are produced in this process, thus Causes blood clots.
Specifically, these two vaccines use adenovirus vectors to deliver the gene sequence encoding the spike protein on the surface of the new coronavirus into the nucleus of human cells, and then the human cells will synthesize the spike protein of the new coronavirus and bind to the cell membrane, thereby Induce an immune response.
According to the conclusions of this study, some instructions for synthesizing the new coronavirus spike protein may be “misread”, so that the originally expected spike protein cannot be synthesized, but a shorter mutant protein. These mutant proteins cannot bind to the cell membrane of human cells like the original spike protein, and cannot trigger an immune response, but will enter the human body through cell secretion, which may cause thrombosis. The probability is about one in 100,000.
In contrast, mRNA vaccines such as Pfizer and Moderna do not need to send genetic instructions to the nucleus, and will not cause thrombosis. The study pointed out that if vaccine manufacturers can modify the gene sequence of the spike protein to prevent the above situation, this may be a way to solve the thrombosis problem.
Masalek said that Johnson & Johnson has contacted its team for guidance to optimize its COVID-19 vaccine. The research results have also been submitted to the German vaccine approval agency Paul Ehrlich Institute and other institutions.
However, some scientists warned that Masalek’s study was only one of many experiments, and further evidence was needed to confirm his claim.
So far, of the 33 million people vaccinated by Johnson & Johnson and AstraZeneca in the UK, 309 people have thrombosis, and 56 of them have died. Among the 16 million vaccinators in other European countries, 142 people have developed thrombotic symptoms. At present, more than ten countries have suspended or restricted the use of AstraZeneca vaccine in their own countries. The promotion of Johnson & Johnson vaccine in Europe has also been postponed, and its label has also marked the corresponding safety warning.
(source:internet, reference only)
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