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Scientists found that food coloring promotes the occurrence of inflammatory bowel disease
Food coloring promotes the occurrence of inflammatory bowel disease. Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease of the intestinal tract, and its incidence tends to increase year by year.
Genetic factors and environmental factors play an important role in the occurrence and development of inflammatory bowel disease, but the pathogenic mechanism caused by environmental factors is still unclear.
Recently, a research team at the Icahn School of Medicine at Mount Sinai in New York found that under certain conditions, food coloring can promote the occurrence of inflammatory bowel disease. The research was published in “Cell Metabolism” magazine with the title: “Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23”.
Studies have found that the inflammatory factor IL-23 plays a key role in the development of inflammatory bowel disease. The researchers first constructed a mouse model with active IL-23 expression. When fed with normal food, mice with active IL-23 expression did not develop colitis. When the mice were fed with specific foods containing lure red pigment, IL-23 Mice with active expression of -23 will develop severe colitis, while mice with inactive IL-23 will not develop colitis if they are fed food with allure red pigment.
Further research found that allure red pigment-induced colitis relies on intestinal microbes. B. ovatus and E. faecalis in the intestines produce a kind called ANSA-Na by metabolizing the lure red pigment. The metabolites, and ANSA-Na will promote the occurrence of colitis. Studies have found that the sunset yellow pigment, which is also an azo dye, also has a similar mechanism of action.
This study shows that when the inflammatory factor IL-23 is active, food colors such as Allure Red and Sunset Yellow can promote the development of colitis in mice. This suggests that food coloring may be one of the environmental factors leading to the occurrence of inflammatory bowel disease.
(source:internet, reference only)