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JAMA: Men who receive the COVID-19 vaccine will not cause a decrease in sperm count
JAMA: Men who receive the COVID-19 vaccine will not cause a decrease in sperm count. Vaccination caused a statistically significant increase in sperm concentration, but the magnitude of the change was still within the normal range of the individual.
Recently, the Journal of the American Medical Association (JAMA) published a study that pointed out that men do not have to worry about the COVID-19 vaccine because of fertility problems, and vaccination will not damage spermatogenesis.
According to Dr. Ranjith Ramasamy, Director of Male Reproductive Medicine and Surgery at the University of Miami, although the current Pfizer and Moderna vaccines are highly effective and safe, the survey shows that only 56% of people want to be vaccinated. One of the reasons for refusal is that they are worried about the vaccine’s impact on fertility. damage. There are comments that the vaccine has not been evaluated for reproductive toxicity in clinical trials, and the virus itself can cause a decline in sperm count, and a vaccine with a similar structure may have the effect of reducing fertility.
Ramasamy recruited 45 healthy male volunteers aged 25-31. They tested negative for the virus and had no fertility problems. The researchers collected a semen sample before the volunteers were vaccinated with the first dose of mRNA vaccine, and collected a second sample 70 days after the second dose of injection to evaluate and compare semen volume, concentration, total number of sperm, and sperm motility.
It was found that the volunteer’s initial baseline sperm concentration was 26 million per milliliter, and the total motile sperm count was 36 million; after vaccination, the sperm concentration increased to 30 million per milliliter, and the total motile sperm count was 44 million. The volume of semen and sperm Vitality has also increased significantly. Before vaccination, 8 out of 45 men were oligospermia, with a sperm concentration of 8.5 million per ml, while 7 men reached the normal range of 22 million per ml after vaccination.
Ramasamy said that the results showed that vaccination caused a statistically significant increase in sperm concentration, but the magnitude of the change was still within the normal range of individuals. It can be considered that the mRNA vaccine has no effect on spermatogenesis, but there is no evidence whether it enhances spermatogenesis. This trial did not involve AstraZeneca or Johnson & Johnson’s COVID-19 vaccine, but because its effective mechanism is similar, it is speculated that the results should be roughly the same. Researchers also need to carry out larger studies on men of different ages to confirm this result.
Allan Pacey, professor of andrology at the University of Sheffield in the United Kingdom, commented that this study shows that receiving two doses of mRNA vaccine will not significantly change the quality of sperm. Male friends who are worried about the reproductive toxicity of the vaccine can be assured of vaccination.
Pacey added that, on the other hand, the new coronavirus may damage male reproductive ability. A small study conducted in January showed that sperm cell inflammation and oxidative stress in male patients with COVID-19 pneumonia were significantly increased, and sperm concentration, vitality, and morphology were all negatively affected by the virus.
The new coronavirus can invade cells through the ACE2 receptor, and this receptor also exists in testicular cells, so the virus may affect the function of the male reproductive system. He said that the impact of the new coronavirus on male fertility may be mild or temporary. Temporary factors such as fever, obesity or other drugs may also affect the quantity and quality of sperm; but on the other hand, such as Zika virus and Ebo Pull virus can be retained in the testes for a long time. Therefore, it will take a longer time to understand whether the new coronavirus will also cause this change.
(source:internet, reference only)