Most comprehensive and detailed summary of key points for COVID-19

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The most comprehensive and detailed summary of key points for COVID-19

Most comprehensive and detailed summary of key points for COVID-19.  Recommended that John Mascola, director of VRC at the National Institutes of Health (NIH), publish a review article on Immunity on August 3, 2021. The title is “Accelerated COVID-19 vaccine development: milestones, lessons, and prospects“.

(John R. Mascola, M.D. Director, Vaccine Research Center (VRC) Credit: NIAID) |  (Barney Graham, M.D., Ph.D. Credit: NIAID)

Mascola is one of the originators of the HIV antibody field and one of the heads of vaccine research and development in the United States. This review by him and Barney Graham, one of the main contributors to the development of COVID-19 vaccines, first summarizes the important time of the COVID-19 epidemic. Line, and then summarized the technical characteristics of all marketed vaccines including Kexing and Sinopharm vaccines.

Highly recommend the target protein column. This is what I always say. The mRNA vector attracts too much attention, but most people ignore the core technology of structure-based antigen design; there is another very important point, that is, vaccines. How to deal with the Furin cleavage site. For example, Moderna and BioNTech both chose native, but Johnson & Johnson’s vaccine chose R682S/R685G.

In the summary of the overall protection of the vaccine, this review summarizes the overall protection of the phase 3 clinical trials of 5 major vaccines and the protection against mutant strains. Then it summarizes the relationship between vaccination and the decline in hospitalization rates in the real world, and finally the real-world protection data of various vaccines.

This review is currently the most comprehensive and detailed summary of the main points of COVID-19.

(source:internet, reference only)

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