September 24, 2021

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Breakthrough infection of Delta: No difference from regular COVID-19 cases



 

Breakthrough infection of Delta: No difference from COVID-19 cases.  Highly vigilant! Once infected with Delta, there is no difference between the breakthrough case and the ordinary case, the viral load is similar, and the transmission is similar.

With the large-scale outbreak of the epidemic in India, the mutant virus delta has gradually become the focus of the world. Delta variant that has been knocking on the country does not seem to stop, making people pin their hopes on the SARS-CoV-2 vaccine.

Breakthrough infection of Delta: No difference from regular COVID-19 cases

However, because the spike protein of the COVID-19 mutant strain delta has a considerable degree of variation, its transmission is comparable to chickenpox, and it will reduce the effectiveness of current vaccine antibodies. Therefore, there have been “breakthrough cases” in some areas. Based on this, the public has raised questions. Can the vaccine reduce the viral load in patients with breakthrough infections and limit the spread of delta?

Recently, a new study led by the University of Wisconsin in the United States explained this question. The study pointed out that whether you are vaccinated or not, the viral load in the body after infection with delta is similar, and patients with breakthrough infection cases can also transmit the virus. To others.

Related research was published on MedRxiv, a health science preprint paper platform under the title of Vaccinated and unvaccinated individuals have similar viral loads in communities with a high prevalence of the SARS-CoV-2 delta variant.

The COVID-19 vaccine is like a training camp for the immune system, which allows the body to adapt to the SARS-CoV-2 virus in advance. “Breakthrough cases” refer to cases that are still infected with the new coronavirus more than 2 weeks after the completion of vaccination. Within a few months or a few years, this particular case of COVID-19 disease may often appear in the public eye.

As we all know, the most common method for detecting the specific sequence of the new coronavirus is fluorescent quantitative PCR, which can monitor the relationship between the number of cycles (Ct value) at which the fluorescence reaches a preset threshold and the concentration of viral nucleic acid. The higher the concentration of viral nucleic acid, the Ct value The smaller.

Therefore, in order to determine whether vaccination can reduce the viral load in patients with breakthrough infections, the researchers collected 83 respiratory samples from SARS-CoV-2 positive patients in Dane County, which has the highest vaccination rate in the United States. Divided into fully vaccinated group and non-vaccinated group, real-time fluorescent RT-PCR method was used to detect the Ct value of samples.

Not only that, the researchers also specifically performed sequencing analysis on 16 positive samples, and surprisingly found that 14 samples were delta variants. And research data shows that there is no significant difference in the viral load of COVID-19 patients regardless of whether they are vaccinated or not.

In further experiments, the researchers expanded the scope of the experiment to 291 samples, of which 73 cases of breakthrough infection. Research data shows that about 84% of breakthrough infection cases have a Ct value of less than 30, and 83% of individuals who have not been vaccinated against SARS-CoV-2 have similar Ct values.

In addition, 33% of breakthrough infections have extremely high viral loads, and gene sequencing results show that 84% of all samples are infected with delta mutant strains. Current research data shows that compared with unvaccinated patients, the virus transmission ability in patients with breakthrough infection is consistent with it.

In fact, the internal documents of the Centers for Disease Control and Prevention (CDC) previously mentioned the views of this latest research and even bolded “no difference.” It is worth noting that the non-profit research group “Kaiser Family Foundation” (Kaiser Family Foundation) analyzed data from the CDC and stated that among the people who have completed the COVID-19 vaccine, patients with breakthrough infections accounted for the total number of patients. The proportion of vaccinated people is less than 0.001%. Therefore, the COVID-19 vaccine is still the most effective weapon against the epidemic virus.

Breakthrough infection of Delta: No difference from regular COVID-19 cases

(source:internet, reference only)


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