March 31, 2023

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Cell Journal: Intermittent fasting has multiple health benefits

Cell Journal: Intermittent fasting has multiple health benefits, but it depends on age and gender


Cell Journal: Intermittent fasting has multiple health benefits.  Time-Restricted Eating (TRE) is a type of intermittent fasting that restricts the diet to a specific time of the day. This diet method has attracted more and more attention in the weight loss circle.

Many previous studies have shown that limited-time diets have a variety of health benefits, but most of these studies were conducted on young male mice. Does this diet have similar benefits for groups of other genders and ages? Woolen cloth?

On August 17, 2021, researchers from Salk Research and the University of Utah published in Cell Reports the title: Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high- A research paper on sucrose diet in C57BL/6J mice.

This study shows that limited-time diets have a variety of health benefits, protecting men, women, and children from fatty liver and glucose intolerance, as well as protecting them from death from sepsis. These health benefits are partly related to gender. For example, a limited-time diet can reduce the weight of young and old male mice, but it is not effective for females. Limited time diet can also maintain and increase muscle mass and improve muscle performance in male mice, but it is also ineffective for females.

This shows that limited time diet is not only beneficial to metabolic diseases, but also can improve resistance to infectious diseases, and can also reduce weight, but some of the health benefits are related to gender.


Cell Journal: Intermittent fasting has multiple health benefits


Glucose intolerance is the first step in non-alcoholic fatty liver and liver cancer. Liver cancer is one of the few cancers whose morbidity and mortality have increased in the past 25 to 30 years. In addition, more and more people suffer from diabetes or pre-diabetes. These trends make finding a simple treatment for glucose intolerance a priority.

The research team broke the model of using only young male mice in most previous studies and gave young female and male mice at the age of 3 months (equivalent to 20 years old in humans) and middle-aged mice at 12 months (equivalent to 42 years old in humans). The female and male mice were fed a high-fat, high-sugar diet, and the eating time was limited to 9 hours a day.

The research team then tested fatty liver, glucose regulation, muscle mass, endurance, and survival rates after infection with sepsis to determine how age and gender affect the results of a limited-time diet on various health parameters. The research team also matched the laboratory conditions with the animal’s biological clock (mice sleep during the day and move at night), working through night vision goggles and special lighting equipment.

After 16 hours of fasting, an oral glucose tolerance test conducted on mice showed that the limited time diet was associated with lower blood glucose rise in male mice and faster return to normal blood glucose levels, and significantly improved the glucose tolerance of female mice. This finding suggests that a limited time diet may be a low-cost or even no-cost, user-friendly method of preventing or treating diabetes.

Researchers also found that limited-time diets can protect males and females from death caused by sepsis, which is a special and common danger in intensive care units, especially during the COVID-19 pandemic. The researchers also injected the mice with a toxin that induces sepsis, and then monitored the survival rate of the mice for 13 days, and found that the limited-time diet protected male and female mice from dying of sepsis.

The researchers also found that these mice, regardless of age, sex, or weight loss, can effectively prevent fatty liver disease with a limited time diet. Fatty liver affects hundreds of millions of people around the world, and there are no approved drugs on the market.

These results show that limited-time diet can not only prevent deaths caused by fatty liver, diabetes and sepsis, but even enable male mice to maintain and increase muscle mass and improve muscle performance (this effect does not apply to females). This finding is especially important for the elderly, because improving muscle performance helps prevent falls.


Cell Journal: Intermittent fasting has multiple health benefits


The research team said that the effect of limited time diet on muscle improvement is very surprising, and the laboratory will further study whether limited time diet helps muscle repair and regeneration, as well as the specific impact on muscle metabolism and regeneration.


(source:internet, reference only)

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