Your DNA will decide when you first had sex and when you became a parent?

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Your DNA will decide when you first had sex and when you became a parent?

People have always been accustomed to using various “sociological” reasons to deal with the soul torture from the Seven Aunts and Eight Aunts——

In July of this year, a research team led by the University of Cambridge, the University of Oxford and the University of Bologna in Italy jointly published a paper, the first time the age at first sexual intercourse (age at first sexual intercourse) AFS) and age at first birth (AFB) are connected with our DNA and try to find the relationship between them.

The related research is titled “Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour” and published in the journal Nature Human Behaviour.

Your DNA will decide when you first had sex and when you became a parent?

Figure 2. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour (Source: Nature Human Behaviour)

As the largest study in this field so far, scientists from the above-mentioned institutions included nearly a million people in the study, and combined multiple data sources to collect information on samples of 387,388 first sexual behaviors and 542,901 first reproductive behaviors.

Later, through the use of genome-wide association analysis (GWAS), they found that: There are 371 autosomal single-nucleotide polymorphisms* (SNPs) sites on DNA, which, together with our environmental factors, affect Two milestone moments in people’s lives-the age when they first had sex, and the age when they were parents for the first time!

*Note: SNP refers to the diversity of DNA sequence caused by the change of a single nucleotide (A, T, C, G) at the genome level. It is the most common type of human heritable variation and accounts for all Know more than 90% of polymorphism.

Among these 371 gene mutation sites, 282 are related to the “first night” age, and 89 are related to the “first birth” age. Among them, 11 are sex-specific, and compared with the age of first sex, the sex-specific genetic correlation of the first childbearing age is higher, and the latter has 10 sex-specific SNPs .

Your DNA will decide when you first had sex and when you became a parent?

Figure 3. Summary of GWAS research results (Image source: Nature Human Behaviour)

This discovery can be described as “unexpected, but reasonable”-when we have the first sexual behavior and when we have children, in fact, it is not only affected by social and environmental factors, but even mixed with a little bit. The meaning of “destined” is inside.

Based on these newly identified genetic markers, the researchers calculated Polygenic Scores (PGS), and the results showed that individuals with higher PGS tend to have their first sex and give birth later.

In addition, these genetic effects are also closely related to environmental factors: children with a higher socioeconomic status (that is, parents’ education level) during childhood have a later first sex and age at childbearing, and individuals with higher PGS who meet the above conditions have more May postpone the time of sex and childbirth.

Researchers also found that people who are genetically inclined to postpone sexual life or have late childbirth have better health in old age and live longer.

Other factors, such as tobacco and alcohol, drugs, ADHD, loneliness, education level, and premature sex and fertility are also strongly linked (Figure 4).

Your DNA will decide when you first had sex and when you became a parent?

Figure 4. The genetic correlation between the age of first sex and the age of first childbirth and other traits (Image source: Nature Human Behaviour)

Using AFS and AFB to measure the start time of human reproductive behavior also has an important impact on reproductive health, adolescent development and evolutionary health.

Studies have shown that premature sexual activity is an important factor in inducing cervical cancer: compared with women who occur at the first night of 21 years or older, the risk of cervical cancer under 17 years of age is twice that of the former.

In addition, depression, sexually transmitted diseases and drug use disorders are also related to it. In contrast, later reproductive behavior is associated with lower fertility, endometriosis, polycystic ovary syndrome, and early menopause and other infertility characteristics.

This study shows that genetic signals are driven by social factors and environment, as well as by reproductive biology.

The joint action of the three determines the advancement and delay of the reproductive period. In this regard, Professor Melinda Mills, the first author of the study and Director of Population Sciences at Oxford University, concluded: “The root cause of premature sex is childhood inequality, which is also related to health problems, such as cervical cancer and depression…

This research has discovered hundreds of genetic markers that shape the most basic parts of our lives and have the potential to gain a deeper understanding of adolescents’ mental and sexual health, infertility, and later life diseases, etc., to help develop corresponding Treatment methods.”

The above research results may be able to resist some of the “urging marriage” and “baby birth” offensives for you, but please pay attention-

Reference:

[1] Nature Human Behaviour:

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

https://doi.org/10.1038/s41562-021-01135-3

[2] British Journal of Cancer:

Comparison of risk factors for squamous cell and adenocarcinomas of the cervix: a meta-analysis

https://doi.org/10.1038/sj.bjc.6601764

Your DNA will decide when you first had sex and when you became a parent?

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