Stress will suppress immune system and weaken the ability to fight cancer

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Stress will suppress the immune system and weaken the ability to fight cancer

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Cell Press: Stress will suppress the immune system and weaken the ability to fight cancer.

In modern society, all aspects of work, life and study bring us stress . The negative emotions brought by these stress machines have a great impact on human health.

Previous studies have shown that stress can cause gray hair , hair loss , and obesity . It can also reduce human immunity, but the specific mechanism by which stress inhibits human immunity is still unclear.

April 13, 2021, Researchers from Western University Canada published a report  in in Cell sub-Journal Cell Reports journa, entitled: Chronic Stress Physically Spares But Functionally impairs innate-like invariant T cells.

The study showed that the pressure -induced hormone (glucocorticoid) weakens congenital T cells (innate-like T cells) cancer-fighting ability, resulting in accelerating the development and proliferation of cancer cells.

This research reminds us that based onThe cancer treatment potential of congenital T cells will be weakened by human psychological pressure, so the psychological pressure of patients needs to be considered when designing and using these therapies .

Research on the effects of stress on the immune system tends to focus on before conventional T cells, so far no study was to investigate the pressure of innate T cells (innate-like T cells) impacts.

Congenital T cells (innate-like T cells) are heterogeneous T lymphocyte, including a constant natural killer T cells ( of iNKT ) and associated with a mucosal innate T cells ( MAIT ) .

iNKT cells exist in small amounts in many tissues, but they are especially abundant in omentum tissues between human organs.

However, MAIT cells exist in higher numbers in human peripheral blood, intestines, lungs, liver and other organs.

These innate T cells are the emergency responders of our immune system .

They are in a pre-activated mode and can quickly respond to invading pathogens and cancer cells , just like a loaded gun, ready to fight back at any time.

Previous studies have suggested that when a person suffers from chronic psychological and emotional stress, the body’s immune system will be suppressed, thereby weakening its ability to fight cancer and infections.

This is largely because stress-induced hormones kill Certain immune cells in the human body.

However, this study by Cell Reports shows that congenital T cells do not actually die due to chronic stress , but their anti-cancer ability is greatly impaired by stress-induced hormones (glucocorticoids) .

The research team observed in mouse models that stress-induced hormones damage congenital T cells, which greatly accelerates the development and spread of cancer cells .

This study shows that although innate T cells can stimulate a powerful anti-tumor immune response under the circumstances , their anti-tumor effect fails in the presence of stress .

Dr. Mansour Haeryfar , the corresponding author of the paper , said that he is currently studying the use of innate T cells for cancer immunotherapy (iNKT cell therapy) .

This research suggests that the cancer treatment potential of innate T cells will be affected by human psychological stress. Attenuation, so the psychological pressure of the patient needs to be considered when designing and using these therapies .

In general, this study found that congenital T cells can survive when the individual is under stress, but their anti-cancer function will be impaired, leading to enhanced cancer cell metastasis.

In addition, the study also reveals the specific mechanism by which stress reduces the ability of T cells to fight cancer.

Therefore, these findings can be used to improve cancer immunotherapy based on innate T cells, so that it is still effective for stressful and stressed patients.

Reference:
https://doi.org/10.1016/j.celrep.2021.108979

Stress will suppress the immune system and weaken the ability to fight cancer.

(source:internet, reference only)

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