September 25, 2022

Medical Trend

Medical News and Medical Resources

High-dose vitamin D does not affect cardiovascular disease or cancer

High-dose vitamin D does not affect cardiovascular disease or cancer


Vitamin D does not prevent cancer! Five-year long-term clinical trial shows that high-dose vitamin D supplementation does not affect the incidence of cardiovascular disease or cancer

Friends, the Chinese New Year is just around the corner, are you ready for the gift boxes for visiting relatives and friends? Are you going to start buying some health care products that you don’t know if they work or not?


Not to mention the other messes, Singularity Cake personally thinks that vitamin tablets can still be prepared, especially in the current situation, if one day I cannot eat at home in isolation, vitamin supplementation is still quite necessary.


However, for those who are not deficient in vitamins, supplementation may not have any superfluous benefits. Take vitamin D, for example. ‘

Scientists had high hopes for it before. After all, vitamin D has shown potential benefits for cardiovascular disease and cancer prevention in many studies , but the results of a recent study really give everyone a little bit Disappointed.


Recently, a research team from the University of Eastern Finland published the results of the FIND trial in the American Journal of Clinical Nutrition. During the 5-year trial period, nearly 2,500 participants supplemented daily vitamin D supplements far beyond the recommended amount, but ultimately did not. Failure to reduce the incidence of cardiovascular disease or cancer [1].


High-dose vitamin D does not affect cardiovascular disease or cancer. 


Vitamin D is an old acquaintance when we discuss dietary supplements. In addition to being closely related to calcium supplementation, vitamin D also shows many other potentials.

Mechanistically, vitamin D affects tumor cell proliferation, apoptosis, cell differentiation, Physiological and pathological manifestations such as angiogenesis, inflammation, vascular smooth muscle proliferation, blood pressure, and blood glucose homeostasis have a positive impact [2-4], and there are also observational data showing that vitamin D deficiency is associated with a high risk of almost all diseases [5] ].


Looking at it this way, it seems that there should be some truth to vitamin D supplementation!


However, it is puzzling that the results of relevant clinical studies are inconsistent.


The largest study, the Women’s Health Initiative (WHI) cohort, found that calcium and vitamin D3 supplementation (400 IU/day) for 7 years had no effect on cardiovascular disease or cancer incidence [6]; another study in older adults Studies have also shown that vitamin D3 supplementation does not reduce the incidence of cardiovascular disease or cancer [7].


However, a meta-analysis published in 2007 showed that vitamin D supplementation was associated with a reduced risk of all-cause mortality [8]; a 4-year clinical trial in postmenopausal women also found that calcium and vitamin D3 supplementation (1100 IU / day) group had a lower risk of cancer [9].


Some researchers have begun to suspect that most of these studies focus on the effect of vitamin D on bone, and the supplemental dose is not high, and many times it cannot lead to significant changes in the concentration of related metabolites in serum. So if you increase the dosage of supplements, will you be able to see significant results?


Large-scale trials have been carried out in many countries, such as the FIND study in Finland. The researchers originally planned to recruit 18,000 participants, but unexpectedly, the target healthy elderly population was not very interested in this study… In the end, only 2,495 participants were recruited, with an average age of 68.2, 43 % are female. Men are over 60 and women are over 65 and postmenopausal.


High-dose vitamin D does not affect cardiovascular disease or cancer. Participants’ baseline characteristics (local)


The participants were divided into three groups, supplemented with 1600IU, 3200IU of vitamin D and placebo every day, and filled out questionnaires on physical conditions, living habits, diseases, and drug use on a regular basis.

Some participants also further detected l serum vitamin D metabolites 25 (OH)D3 levels. The primary endpoints of the trial were invasive cancer types and major cardiovascular events.


During the 5-year period of the trial, 119 participants developed cardiovascular disease, 129 developed cancer, and 19 died, but there were no differences in frequency among the three groups, meaning that vitamin D supplementation did not Can prevent cancer and cardiovascular disease .


High-dose vitamin D does not affect cardiovascular disease or cancer. Vitamin D does not reduce cardiovascular disease and cancer rates


But on the bright side, there is no difference in the side effects between the high-dose group and the low-dose group, and excessive vitamin D supplementation is quite safe…


Of the participants who had further blood tests, only 9 percent had low vitamin D levels of less than 20 ng/ml at baseline.


It can be seen that for people who are not deficient in vitamin D, supplementation will not bring benefits in cardiovascular disease or cancer.

Maybe supplementation will be beneficial for those who are deficient in vitamin D, but this Follow-up experiments are also needed.




[2] Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci 2009;338:40-4.

[3] Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global perspective. Ann Epidemiol 2009;19:468-83.

[4] Manson JE, Bassuk SS. Vitamin D and cardiovascular disease. Meno Management 2009;18:28-31.

[5] Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, et al. Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocr Rev 2019;40:1109-51.

[6] Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-83.

[7] Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003;326:469.

[8] Autier P, Gandini S. Vitamin D supplementation and total randomized mortality: a meta-analysis of controlled trials. Arch Intern Med 2007;167:1730-7.

[9] Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85:1586-91.


High-dose vitamin D does not affect cardiovascular disease or cancer. 

(source:internet, reference only)

Disclaimer of