Eisai/Biogen Announced New Study Results of Lecanemab for Alzheimer’s Disease
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Eisai/Biogen Announced New Study Results of Lecanemab for Alzheimer’s Disease
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Eisai/Biogen Announced New Study Results of Lecanemab for Alzheimer’s Disease.
On April 27, Eisai issued a press release stating that it has published an article on long-term health outcomes using simulation modeling with the Aβ antibody Lecanemab in patients with early Alzheimer’s disease (AD) in Neurology and Therapy.
The results suggest that Lecanemab may slow the rate of AD progression, allowing treated patients to remain in the early stages of AD-induced mild cognitive impairment (MCI) for longer.
Based on data from the Phase IIb clinical trial (BAN2401-G000-201) evaluating the efficacy and safety of Lecanemab and published literature, we used disease models to predict and compare the presence of amyloidosis with Lecanemab plus standard of care (SOC) versus SOC alone. Long-term clinical outcomes in patients with early AD.
The results showed that compared with SOC, the lifetime risk of disease progression to mild, moderate and severe AD in the Lecanemab+SOC group may be reduced by 7%, 13% and 10%, respectively; patients in the Lecanemab treatment group developed mild, moderate and severe AD.
The mean duration of severe AD was prolonged by 2.51 years (3.10 vs 5.61 years), 3.13 years (6.14 vs 9.27 years), and 2.34 years (9.07 vs 11.41 years).
The study also showed that the earlier Lecanemab treatment was started, the greater the potential impact on disease progression. In a subgroup analysis, the incremental mean time to transition to mild and moderate AD dementia was 2.53 and 3.34 years, respectively, when treating MCI caused by AD compared with SoC.
Eisai/Biogen Announced New Study Results of Lecanemab for Alzheimer’s Disease
(source:internet, reference only)
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