5 reasons why the creatinine of kidneypatients rises quickly

5 reasons why the creatinine of kidney patients rises quickly. Take measures separately, uremia will not come easily.

Patients with chronic kidney disease (CKD) are most afraid of rapid increase in blood creatinine, which is an important indicator of the severity of kidney function. If the blood creatinine rises too fast, it means that the condition of the CKD patient is worsening or progressing rapidly.

The rapid rise of blood creatinine will not only rapidly develop to uremia that must be treated by renal replacement, but also life-threatening complications and comorbidities will occur. As a result, it will not only affect the quality of life of patients with kidney disease, but also increase the risk of death.

When chronic kidney disease (CKD) progresses to CKD stage 2, the patient’s serum creatinine begins to rise. However, in most cases, blood creatinine can remain relatively stable for a long time or rise slowly. If you find that the blood creatinine of a patient with CKD rises quickly, you need to go to the hospital to see a doctor and find out the reason behind it, to see why the blood creatinine rises so quickly?

Generally speaking, the blood creatinine of patients with chronic kidney disease rises quickly, mainly due to the following five major reasons. Corresponding measures should be taken respectively, so that uremia will not come easily.

1. There are aggravating factors

The blood creatinine is suddenly higher. First find the cause in the patient with chronic kidney disease, that is, whether there are aggravating factors, such as cold and cold, cough and fever, profuse sweating, high temperature work, bleeding, unclean eating, and eating too much , Abdominal pain, diarrhea, dysuria, frequent staying up late, overwork and strenuous exercise, etc., all of which can cause a rapid increase in serum creatinine in patients with nephropathy. After finding out these reasons, you can take targeted treatment measures. Inducing factors related to infection, such as cold, cold, cough and fever, abdominal pain, diarrhea, and urgency and dysuria, active anti-infection treatment is required; excessive sweating, high temperature work, and more bleeding are complications of prerenal acute kidney injury leading to blood creatinine The rapid increase, the main treatment measures are to supplement and supplement blood volume, while giving symptomatic treatment; other such as eating too much, often staying up late, overworked and strenuous exercise, etc., need to immediately correct these bad eating and living habits. Take the above measures in time, and the elevated blood creatinine can be reduced to the original or normal level.

2. Complicated with acute renal failure

The blood creatinine suddenly rises a lot, and there are other reasons, such as acute renal failure, which is also the more common reason for the rapid increase in blood creatinine. Membranous nephropathy and other nephrotic syndromes complicated by idiopathic acute renal failure, the patient’s serum creatinine will rise quickly; lupus nephritis, which manifests as nephrotic syndrome, is prone to complicated with acute renal failure, and the patient’s serum creatinine will also rise quickly; And so on. This is often related to factors such as immune inflammation, renal interstitial edema or disease activity. The treatment measures can be anti-inflammatory and immunosuppressive agents, diuretic swelling and control of disease activity, etc., which can reduce the elevated serum creatinine .

3. Urine protein is too high

If the urine protein of patients with chronic kidney disease is too high, it will also cause the blood creatinine to rise quickly, but it is different from the “exacerbating factors” and “complicated with acute renal failure” in “1” and “2” above. The rise is not so fast, and patients with chronic kidney disease who are not too high in urine protein are still much faster. That is to say, in the medium and long term, patients with chronic kidney disease with too high urine protein progress faster than those with normal or not too high urine protein.

This is mainly seen in chronic kidney disease where the 24-hour urine protein quantitative exceeds 1.0 g (moderate proteinuria) or even more than 3.5 g (large proteinuria). For example, IgA nephropathy with a 24-hour urine protein quantitative of about 2.0 grams, another example is a membranous nephropathy with a 24-hour urine protein quantitative of more than 4.0 grams, or a 24-hour urine protein quantitative of 2.0-3.0 grams of lupus nephritis, etc. They all progress relatively fast, and their blood creatinine rises quickly. Protein-lowering drugs should be selected according to the specific condition, such as sartan/pril drugs, tripterygium polyglycoside tablets, glucocorticoids, cytotoxic drugs or immunosuppressants, etc. It can also be combined with Chinese medicine and Chinese medicine.

4. Uncontrolled blood pressure

Chronic kidney disease can cause renal hypertension, and uncontrolled hypertension can in turn aggravate or promote the progress of chronic kidney disease, leading to a rapid increase in blood creatinine.

Primary hypertension is complicated by hypertensive renal damage, and the patient’s serum creatinine will increase when it develops to the severe stage of chronic kidney disease; secondary hypertension is caused by chronic kidney disease and develops to the severe stage of chronic kidney disease. The blood creatinine will also increase. Whether it is primary or secondary, as long as the blood pressure is not controlled to reach the target, the patient’s serum creatinine will rise at a faster rate.

Adjusting or adding antihypertensive drugs can prevent or delay the increase in blood creatinine. Sartan drugs (such as telmisartan, etc.), pristine drugs (such as lisinopril, etc.), dipine drugs (such as amlodipine besylate), lohr drugs (such as metoprolol tartrate) Er, etc.), oxazosin drugs (such as terazosin, etc.) and diuretic drugs (such as hydrochlorothiazide, etc.) can be selected according to the condition.

5. Chronic kidney disease has reached the middle and late stages

Generally speaking, from stage 1 to stage 3a of chronic kidney disease, the progress of the patient’s condition is relatively slow, and the blood creatinine does not change much or only rises slowly. However, when chronic kidney disease develops to stage 3b to stage 5, the patient’s condition will continue to progress relatively quickly, and the more the disease progresses towards the end, the faster the progression of the condition and the increase in blood creatinine.

Complications and complications of CKD stage 3b to stage 5 patients will also increase and serious, and actively treat these complications and comorbidities and correct abnormal indicators, such as hypertension, anemia, acidosis, hyperphosphatemia, hypocalcemia There is still hope to delay the progression of chronic kidney disease and slow down the rapid rise of blood creatinine, as well as secondary hyperparathyroidism, heart failure and lung infections. Although it cannot stop its development speed, its treatment is still valuable.

During the long course of the disease, blood creatinine often rises quickly. Friends with kidney disease should not be anxious and discouraged. As long as the cause can be found and targeted treatment measures can be taken, uremia will not come so easily.

(source:internet, reference only)

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