November 28, 2021

Medical Trend

Medical News and Medical Resources

What is Penta-component vaccine?

What is Penta-component vaccine?

What is Penta-component vaccine? Penta-component vaccine is a combination vaccine produced by French Pasteur that contains inactivated polio vaccine, acellular DTP vaccine and Haemophilus influenzae type B vaccine, which can replace polio vaccine and DTP vaccine. Vaccination of Penta-component vaccine can prevent five diseases at the same time, including diphtheria, pertussis, tetanus, meningitis caused by Haemophilus influenzae type b, pneumonia, pericarditis, bacteremia, epiglottitis and polio.

The meaning of vaccination

The immunogenicity of the Penta-component vaccine is no different from that of the three vaccines. The child is well tolerated after vaccination, and the seroprotection rate is close to 100%. Both the American Academy of Family Physicians and the American Advisory Committee on Immunization recommend the use of combined vaccines, believing that Penta-component vaccine minimizes the number of injections from 12 doses to 4 doses, reducing the risk of pain and adverse reactions caused by the number of doses, and reducing parents The time and energy spent on vaccinating babies can also improve compliance with immunization. Compared with separate vaccination, the combination vaccine is recommended first.

Way of inoculation

At 2, 3, 4 months of age, or 3, 4, and 5 months of age, 3 doses of basic immunization; 1 dose of booster immunization at 18 months of age.
This product is injected intramuscularly. The best injection site for infants is the anterolateral thigh (middle third).
For infants who have not completed the basic immunization program (that is, less than 3 doses), they can usually consider continuing the vaccination.


People who are allergic to any group of this product or to whooping cough vaccine (acellular or whole cell whooping cough vaccine), or have had a life-threatening adverse reaction to a vaccine containing the same components before, and those with progressive encephalopathy who have previously received whooping cough vaccine People who have suffered from encephalopathy in the last 7 days must postpone vaccination of this product during fever or acute illness.


1. It should be used with caution in people with thrombocytopenia coagulopathy (because of the risk of bleeding after intramuscular injection).

2. Penta-component vaccine may contain a small amount of glutaraldehyde, neomycin, streptomycin and polymyxin B. It should be used with caution in vaccinators who are allergic to these substances.

3. If you have ever had non-febrile seizures unrelated to the previous vaccination, you should carefully consider vaccinating Penta-component vaccine.

4. If any of the following situations may be temporarily related to vaccination, it is necessary to carefully decide whether to further vaccination containing pertussis vaccine:

①Fever ≥40℃ that occurs within 48 hours and is not caused by other clear causes;
②Prolapse or shock-like symptoms appear within 48 hours after vaccination;
③Crying that lasts for more than 3 hours within 48 hours after vaccination;
④ Convulsions with or without fever occur within 3 days after vaccination.

5. If Guillain-Barré syndrome or brachial neuritis occurs after previous vaccination containing tetanus toxoid vaccine, the benefits and possible risks of vaccination containing tetanus toxoid vaccine should be carefully considered. For infants whose basic immunization program has not been completed (ie vaccination <3 doses), it is usually considered to continue vaccination.

6. If you are receiving immunosuppressive therapy or suffer from immunodeficiency disease; the body may reduce the immune response to the vaccine. Therefore, it is recommended to vaccinate after treatment.

7. When vaccinating preterm infants born ≤ 28 weeks of pregnancy, the potential risk of asphyxia and necessary 48-72 hours respiratory monitoring should be considered, especially for those infants with a history of respiratory hypoplasia.

8. When the baby suffers from acute infectious diseases, such as colds, diarrhea, etc., uses immunosuppressants and hormones, and has congenital heart disease, severe liver and kidney disease, severe eczema, and congenital immune deficiency, do not Take the risk of vaccinating your baby.

9. Before vaccination, parents should understand the vaccine’s varieties, effects, contraindications, adverse reactions, precautions, expenses, compensation methods for abnormal reactions, etc., and truthfully provide medical staff with the child’s health status and vaccination contraindications.

10. After the vaccination, the child should be observed in the vaccination place for 30 minutes and can leave after no special circumstances. Individual children may experience transient fever, redness, swelling, induration, pain and other reactions after vaccination. Generally, special treatment is not required and can be relieved by themselves. If there is an adverse reaction listed in the vaccine manual, it is necessary to go to the hospital for diagnosis and treatment in time, and inform the vaccination unit of the reaction.

11. When inoculating, make sure that the injection of this product cannot pass through the blood vessel (the needle must not pierce the blood vessel) or intradermal injection.

Adverse reactions

After vaccination, common systemic and local adverse reactions will occur, including fever, diarrhea, vomiting, loss of appetite, lethargy, crying, tenderness at the inoculation site, erythema, and induration.

Attention: The above content for reference only. The use of vaccines must be carried out under the guidance of a doctor in a hospital or licensed clinic.