Science: Hypertension drugs may affect the function of the body’s brain!
- Probiotics may promote tumor progression?
- Taiwan Professor: Big data confirms that the COVID-19 vaccine is ineffective
- Why are the majority of Monkeypox infected people who have sex with men (MSM)?
- Experimental treatment improves skin cancer survival by 25%
- People who get flu vaccine are 40% less likely to develop Alzheimer’s disease
- Depriving women of the right to abortion is a setback for medical health and society
Science: Hypertension drugs may affect the function of the body’s brain!
- How long can the patient live after heart stent surgery?
- More than 500 new drugs for blood diseases are in development
- Keytruda: The 5-year survival rate for advanced lung cancer doubled!
- Amylyx released the latest statistical analysis of new ALS drugs after being opposed by FDA panel last month
- Celine Dion is paralyzed due to muscle cramps: What are Muscle Cramps?
- Taiwan death from COVID-19 vaccination exceeds death from COVID-19
- The world top 5 best-selling drugs in 2020
Science: Hypertension drugs may affect the function of the body’s brain!
Angiotensin-converting enzyme (ACE, Angiotensin-converting enzyme) can regulate the body’s blood pressure by cleaving angiotensin I to produce angiotensin II.
In the brain, ACE is particularly abundant in striatum tissue, but ACE is in the striatum. The functions in the body circuits are still poorly understood by researchers.
Recently, in a research report titled “Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid” published in the international journal Science , scientists from the University of Minnesota School of Medicine and other institutions found through research that blood pressure drugs may It has unexpected effects on the brain of the body.
Drugs used to treat high blood pressure may unexpectedly increase the effects of opioids produced by the brain in its natural state, researchers have found, which may fine-tune the function of specific brain circuits and counteract treatments such as fentanyl Addiction of painful opioids. “Our findings reveal a novel strategy that may boost opioid signaling in the brain in a protective and beneficial way, with a higher risk of dependence or addiction,” said researcher Patrick Rothwell. Low.
The researchers focused on ACE, which has long been thought to regulate the body’s blood pressure, yet little is known about its specific function in the brain. Based on the results of this paper, the next step for researchers is to study ACE inhibitors, a class of safe drugs used to control the body’s blood pressure that could potentially be redesigned to help treat brain disorders.
Image source: https://www.science.org/doi/10.1126/science.abl5130
The research program was led by investigator Brian Trieu, who collaborated to develop a novel ACE inhibitor designed to optimize the inhibitor’s effect on macrofunction.
Taken together, the results of this study suggest a very attractive prospect that central ACE inhibitors may enhance the transmission of endogenous opioid signaling, thereby allowing patients to obtain certain clinical benefits and reducing the body’s risk of addiction. .
Reference:
DOI:10.1126/science.abl5130
Science: Hypertension drugs may affect the function of the body’s brain!
(source:internet, reference only)
Disclaimer of medicaltrend.org
