June 27, 2022

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Science:  Hypertension drugs may affect the function of the body’s brain!

Science:  Hypertension drugs may affect the function of the body’s brain!



 

Science:  Hypertension drugs may affect the function of the body’s brain!


Angiotensin-converting enzyme (ACE, Angiotensin-converting enzyme) can regulate the body’s blood pressure by cleaving angiotensin I to produce angiotensin II.

In the brain, ACE is particularly abundant in striatum tissue, but ACE is in the striatum. The functions in the body circuits are still poorly understood by researchers.

 

Recently, in a research report titled “Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid” published in the international journal Science , scientists from the University of Minnesota School of Medicine and other institutions found through research that blood pressure drugs may It has unexpected effects on the brain of the body.

 

Drugs used to treat high blood pressure may unexpectedly increase the effects of opioids produced by the brain in its natural state, researchers have found, which may fine-tune the function of specific brain circuits and counteract treatments such as fentanyl Addiction of painful opioids. “Our findings reveal a novel strategy that may boost opioid signaling in the brain in a protective and beneficial way, with a higher risk of dependence or addiction,” said researcher Patrick Rothwell. Low.

 

The researchers focused on ACE, which has long been thought to regulate the body’s blood pressure, yet little is known about its specific function in the brain. Based on the results of this paper, the next step for researchers is to study ACE inhibitors, a class of safe drugs used to control the body’s blood pressure that could potentially be redesigned to help treat brain disorders.

 

Science:  Hypertension drugs may affect the function of the body's brain!

Image source: https://www.science.org/doi/10.1126/science.abl5130

 

The research program was led by investigator Brian Trieu, who collaborated to develop a novel ACE inhibitor designed to optimize the inhibitor’s effect on macrofunction.

Taken together, the results of this study suggest a very attractive prospect that central ACE inhibitors may enhance the transmission of endogenous opioid signaling, thereby allowing patients to obtain certain clinical benefits and reducing the body’s risk of addiction. .

 

 

 

 

Reference:

 DOI:10.1126/science.abl5130

Science:  Hypertension drugs may affect the function of the body’s brain!

(source:internet, reference only)


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