Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed

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Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed

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Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed.

The US epidemic is gradually worsening, with rapid increases in COVID-19 cases reported across the country.

Generally speaking, this wave of symptoms are mostly atypical, with headache and runny nose as the main symptoms; very similar to the flu.

So readers still need to be vigilant, so as not to overlook. If you feel unwell, test yourself in time; once confirmed, isolate yourself in time, especially protect the elderly and people with low immunity at home.

To be honest, for seasonal diseases such as influenza, most young and middle-aged people do not care. As long as there are no sequelae.

But COVID-19 is not reassuring on this point; because the proportion of long COVID is much higher than that of influenza.

On August 31, 2023, Nature Med published a long COVID cohort study from Oxford University, which prospectively identified two biomarkers that cause cognitive impairment or brain fog in long COVID patients.

Speaking of brain fog, most readers may not understand; but if you talk about “brain not working”, many people may have different feelings.
Brain not working after COVID-19 infection? Beware of “brain fog”!

In these prospective cohort studies, researchers found that among COVID-19 survivors who had long-term sequelae such as brain fog or cognitive impairment, two biomarkers were significantly elevated during the acute phase of COVID-19: one was the ratio of fibrinogen/CRP; the second was the ratio of D-dimer (DD dimer)/CRP.

These two biomarkers still have relevance to long COVID cognitive impairment in other unrelated cohorts.

It can be speculated that long COVID cognitive impairment may be related to coagulation function and thrombosis formation.

From a clinical perspective:

• The impact of COVID-19 is not limited to acute respiratory problems, many patients still suffer from “long-term COVID” problems after recovery, including brain fog and other cognitive deficits. Although these sequelae have attracted widespread attention in society, their biological basis remains a mystery.
• This study provides us with important clues about the possible biological causes of these elusive symptoms. In particular, these biomarkers may become key tools for screening and predicting which COVID-19 patients are more likely to develop long-term cognitive problems.
• From a clinical research perspective, this provides new ideas and directions for future treatment strategies, especially for the treatment of long-term COVID patients.

From a scientific perspective:

The design of this study is very simple, but it solves an important and unresolved problem; it also verifies again the two key resources for clinical research:

• A, long-term follow-up patient cohort,
• B, samples collected from publication start

Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed.

references
【1】 Taquet M, et al; PHOSP-COVID Study Collaborative Group. Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization. Nat Med. 2023 Aug 31. doi: 10.1038/s41591-023 -02525- y. Epub ahead of print. PMID: 37653345.

(source:internet, reference only)

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