June 25, 2024

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Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed

Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed


Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed.

The US epidemic is gradually worsening, with rapid increases in COVID-19 cases reported across the country.

Generally speaking, this wave of symptoms are mostly atypical, with headache and runny nose as the main symptoms; very similar to the flu.

So readers still need to be vigilant, so as not to overlook. If you feel unwell, test yourself in time; once confirmed, isolate yourself in time, especially protect the elderly and people with low immunity at home.

To be honest, for seasonal diseases such as influenza, most young and middle-aged people do not care. As long as there are no sequelae.

But COVID-19 is not reassuring on this point; because the proportion of long COVID is much higher than that of influenza.

On August 31, 2023, Nature Med published a long COVID cohort study from Oxford University, which prospectively identified two biomarkers that cause cognitive impairment or brain fog in long COVID patients.


Biomarkers for post-COVID "brain fog" or "cognitive impairment" confirmed.

Speaking of brain fog, most readers may not understand; but if you talk about “brain not working”, many people may have different feelings.
Brain not working after COVID-19 infection? Beware of “brain fog”!

In these prospective cohort studies, researchers found that among COVID-19 survivors who had long-term sequelae such as brain fog or cognitive impairment, two biomarkers were significantly elevated during the acute phase of COVID-19: one was the ratio of fibrinogen/CRP; the second was the ratio of D-dimer (DD dimer)/CRP.

Biomarkers for post-COVID "brain fog" or "cognitive impairment" confirmed.


These two biomarkers still have relevance to long COVID cognitive impairment in other unrelated cohorts.
Biomarkers for post-COVID "brain fog" or "cognitive impairment" confirmed.

It can be speculated that long COVID cognitive impairment may be related to coagulation function and thrombosis formation.

From a clinical perspective:

  • The impact of COVID-19 is not limited to acute respiratory problems, many patients still suffer from “long-term COVID” problems after recovery, including brain fog and other cognitive deficits. Although these sequelae have attracted widespread attention in society, their biological basis remains a mystery.
  • This study provides us with important clues about the possible biological causes of these elusive symptoms. In particular, these biomarkers may become key tools for screening and predicting which COVID-19 patients are more likely to develop long-term cognitive problems.
  • From a clinical research perspective, this provides new ideas and directions for future treatment strategies, especially for the treatment of long-term COVID patients.


From a scientific perspective:

The design of this study is very simple, but it solves an important and unresolved problem; it also verifies again the two key resources for clinical research:

  • A, long-term follow-up patient cohort,
  • B, samples collected from publication start





Biomarkers for post-COVID “brain fog” or “cognitive impairment” confirmed.

【1】 Taquet M, et al; PHOSP-COVID Study Collaborative Group. Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization. Nat Med. 2023 Aug 31. doi: 10.1038/s41591-023 -02525- y. Epub ahead of print. PMID: 37653345.

(source:internet, reference only)

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