October 18, 2021

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Melatonin helpful to treat COVID-19 pneumonia?

Melatonin helpful to treat COVID-19 pneumonia?

Melatonin helpful to treat COVID-19 pneumonia? Accroding to recent news, in a research report published in the international journal PLoS Biology, scientists from the Cleveland Clinic and other institutions found through research that melatonin may be expected as a new treatment for COVID-19. Melatonin is a hormone molecule that can regulate the body’s wake-up cycle, and it is usually used as an over-the-counter sleeping pill.

In this study, researchers have developed a new type of artificial intelligence platform to help identify some possible drugs that are expected to treat COVID-19. Researchers have found that melatonin may be expected as a candidate drug therapy for COVID-19.

After analyzing the data of COVID-19 patients registered in the Cleveland Clinic, the researchers said that after adjusting for age, race, smoking history, and multiple disease complications, participants using melatonin may reduce SARS- by about 30%. The possibility of a positive CoV-2 test. It is worth noting that for the African American population, if the same variables are adjusted, the probability of a positive virus test will increase from 30% to 52%.

Researcher Dr. Feixiong Cheng said these findings do not mean that people can take melatonin on their own without consulting a clinician. Large-scale observational studies and randomized controlled trials in the later period are essential to confirm the clinical therapeutic efficacy of melatonin for COVID-19 patients. In this study, we have found the correlation, and we will further study in the later period. .

In the article, researchers used network medicine methods and large-scale electronic health records from clinic patients to conduct research, and identified common clinical manifestations and pathological mechanisms between COVID-19 and other diseases. In particular, researchers have In the classification of diseases, the degree of closeness between the host body gene and 64 other diseases related to it is measured. The closer the two are, the greater the possibility of pathological relevance between the diseases. These diseases include malignant diseases. Cancer, autoimmune diseases and cardiovascular diseases, etc.

The researchers said that proteins related to respiratory distress syndrome and sepsis (two major causes of death in severe COVID-19 patients) or a variety of SARS-CoV-2 proteins are highly correlated, which may tell the researchers, The use of drugs that have been approved for the treatment of these respiratory diseases may be able to target a common biological target, thereby exerting some utility in the treatment of COVID-19. In the end, the researchers found that autoimmune diseases, lung diseases, and neurological diseases have obvious network similarities to the white matter of SARS-CoV-2. In addition, they also identified 34 drugs or candidates for redirection. Medicine, melatonin is one of them.

Finally, the researcher Cheng said that recent research results indicate that COVID-19 is a systemic disease that affects multiple cell types, tissues and organs. Therefore, understanding the complex interactions between viruses and other diseases may reveal COVID-19. Complications and the key to identifying new redirect drugs.

The research in this article provides a powerful and comprehensive network medicine strategy that may help researchers predict the performance of COVID-19-related diseases and promote the progress of scientists in finding new and effective treatments.