November 28, 2022

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JMT: Principles of Japanese immune cell therapy

JMT: Principles of Japanese immune cell therapy

JMT: Principles of Japanese immune cell therapy. NK cell therapy patented technology to enhance innate immune activity.

Multivalent dendritic cell vaccine

About dendritic cells

Dendritic cells were first discovered in 1868, but the formal study was carried out by Dr. Ralph Steinman and his team in Canada. They learned that they are powerful in 1973. New cells with antigen presentation function. It is named dendritic cell because its shape extends in all directions like a protruding branch.

The so-called antigen presentation function is that when viruses or bacteria invade the body, or when cancer cells occur, these substances are regarded as foreign bodies. Then it will ingest and decompose on its own, and part of it will serve as an antigen (marking of foreign matter) to deliver marker messages to the cell surface.

Although there are cells with antigen-presenting functions other than dendritic cells, their capacity is less than one percent of dendritic cells. Because dendritic cells can exert the most effective antigen presentation ability, they are also called “command towers of the immune system”

Dr. Steinman has made great achievements in “Analysis and Research on the Role of Dendritic Cells and Acquired Immunity” and won the Nobel Prize in Physiology and Medicine in 2011.

About multivalent dendritic cell vaccines

The multivalent dendritic cell vaccine is an immunotherapy that utilizes the excellent antigen presentation function of dendritic cells. Dendritic cells play a role in providing T cells with information about the target cancer antigen (cancer marker). After receiving the cancer antigen information, T cells attack this cancer cell in a precise way. Since normal cells will not be attacked, there are almost no side effects, and the body burden is very small, so even the elderly can receive treatment. In addition, because cancer cells are attacked at the molecular stage, invasive cancer that is difficult to remove by surgery (in situ cancer becomes invasive cancer after breaking through the basement membrane) or cancer cells flowing through the lymph and blood can also be attacked, so it can be said to be right Metastasis and prevention of recurrence are effective.

We use patented technology to obtain a small amount of blood from patients to make vaccines. The multivalent dendritic vaccine uses 4 to 8 cancer antigens to match each patient’s cancer.

 JMT: Principles of Japanese immune cell therapy  

 

The process of treatment

1. Medical consultation

According to the patient’s “cancer information” (blood tests, diagnostic images, etc.) and the factors that may affect treatment, medical-related information including “patient information” (current physical problems, work, lifestyle, family), etc., from the standard Many medical resources, including treatment, discuss with patients to provide patients with the best treatment plan.

2. First inspection

If you choose to use a multivalent dendritic cell vaccine for treatment, first perform HLA (human leukocyte antigen, Chinese: human leukocyte antigen) test, tumor index, and infection check

3. Blood draw and injection

Repeated intravenous blood draws and injections every 2 weeks. (1 course of treatment is 6 injections).

  • ※ When combined with active NK cell therapy, 5 injections are a course of treatment.
  • ※ According to patented technology, no blood component separation (blood separation) is required
  • ※ Blood sampling is to collect blood through a normal vein.
  • ※ The vaccine is injected intradermally.

4. Evaluation of treatment

In this hospital, immune profile analysis is used as one of the evaluation indicators for “before treatment”, “immediately after the end of a course of treatment” and “three months after the end of a course of treatment”.

After a course of treatment, QOL (Quality of Life) is immediately evaluated, and treatment is evaluated based on immune profile analysis test or tumor index and imaging diagnosis.

In addition, three months after the end of a course of treatment, QOL (Quality of Life) was evaluated again, and treatment was evaluated based on immune profile analysis test, tumor index and imaging diagnosis, and future plans were discussed with the patient.

JMT: Principles of Japanese immune cell therapy

Side effects

Because it uses the patient’s own immune cells and immune system, it has almost no side effects.

In a small number of people, the strong immune response within a few hours after the injection may cause chills or fever of 37-38 degrees, but it will subside in about half a day. In addition, the injection site may be red and swollen, but it will disappear in about one night.

  • Adaptation to diseases and conditions
  • Cancer (various stages of cancer), cancer prevention, recurrence prevention
  • Training facilities and support system
  • Cell Processing Center (CPC)
  • The key part of immunotherapy is cell culture. This hospital has an independent cell culture center.
  • The level of aseptic culture facilities used in this hospital has reached the standards of pharmaceutical companies, and the isolator used in production has reached
  • A (class100) cleanliness.

With the guarantee of a complete system, we can avoid infection of bacteria and viruses and cultivate immune cells that are vital to patients.

In addition, the center uses a computer system to manage the cell culture project, which can eliminate human errors in the process of cell culture.

Integrate the most cutting-edge cell therapy support system to provide patients with treatment based on evidence.

Active NK cell therapy

JMT: Principles of Japanese immune cell therapy

NK cell therapy patented technology to enhance innate immune activity

Natural killer cells (NK cells) are lymphocytes that exist in the innate immune system and do not accept instructions from other cells. As long as they find foreign objects such as cancer cells, they will attack. Natural killer: It is an inborn killer, which is why it is called a natural killer.

It constantly patrols the body and monitors cancer cells and foreign bodies, but usually the activity of NK cells declines after reaching a peak around the age of 20. The reasons for the low activity of NK cells include aging, stress, lack of sleep, diet and the influence of drugs. In addition, the activity will be interfered by cancer cells. In order to avoid the attack of NK cells, cancer cells release cytokines (messaging substances) to NK cells and try to inhibit their effects.

If the activity of NK cells decreases and their function deteriorates, there will be more cancer cells that cannot be treated.

Therefore, this hospital has developed a technology to culture NK cells in large quantities in vitro, activate them and inject them back into the body. This is active NK cell therapy.

This treatment method uses the power of activated NK cells to fully resist cancer and enhance innate immunity.

The typical method of identifying cancer cells of NK cells is to use the MHC (major histocompatibility complex, Chinese: major histocompatibility complex gene) type I receptor on the surface of NK cells to check whether the counterparty is a normal cell.

Normal cells will have MHC (major histocompatibility complex, Chinese: major histocompatibility complex gene) class I molecules. Cells that do not contain MHC class I molecules are judged as foreign bodies and begin to attack immediately.

However, some cancer cells also emit MHC class I molecules. So unfortunately, NK cells cannot attack all cancer cells.

 

The process of treatment

1. Medical consultation

According to the patient’s “cancer information” (blood tests, diagnostic images, etc.) and in order to understand the factors that may affect treatment, medical-related information including “patient information” (current physical problems, work, lifestyle, family), etc., from including Many medical resources, including standard treatment, discuss with patients to provide patients with the best treatment plan.

2. First inspection

If you choose to use active NK cell therapy, first check the tumor index and infection

3. Blood draw and injection

Repeated intravenous blood draws and injections every 2 weeks.

(1 course of treatment is 6 injections).

  • ※ When multivalent dendritic cells are used together, 5 injections are a course of treatment.
  • ※ When a multivalent dendritic cell vaccine is used at the same time, no blood draw is required.
  • ※ When performed alone, blood is drawn through a normal vein.
  • ※ The injection is performed by intravenous drip.

4. Evaluation of treatment

After a course of treatment, QOL (Quality of Life) is immediately evaluated, and treatment is evaluated based on immune profile analysis test or tumor index and imaging diagnosis. In addition, three months after the end of a course of treatment, QOL (Quality of Life) was evaluated again, and treatment was evaluated based on immune profile analysis test, tumor index and imaging diagnosis, and future plans were discussed with the patient.

Side effects

Because it uses the patient’s own immune cells and immune system, there are few side effects.

In a small number of people, the strong immune response within a few hours after the injection may cause chills or fever of 37-38 degrees, but it will subside in about half a day. In addition, the injection site may be red and swollen, but it will disappear in about one night.

Adaptation to diseases and conditions

  • Cancer (various stages of cancer), cancer prevention, recurrence prevention, anti-aging
  • Active NK/NKT/γδT cell therapy
  • Enhance innate immune activity NK/NKT/γδT cell therapy patented technology
  • NK cells, NKT cells and γδ T cells are a kind of lymphocytes that play a role in the innate immune system. These cells are not instructed by other immune cells, and individual cells use their own receptors to recognize and attack cancer cells.

However, since NKT cells and γδ T cells also have the characteristics of T cells, they can be activated by dendritic cells like killer T cells, and can recognize cancer cells and directly attack them sharply. γδT cells have a variety of receptors on the cell surface, and can very sensitively detect changes in normal cell canceration.

Our hospital has developed a technology to culture NK cells, NKT cells, and γδT cells in a balanced manner in vitro, and then put them back into the body after activation.

Using these activated immune cells to fully resist cancer and enhance innate immunity is called “active NK/NKT/γδ T cell therapy.”

Put it back into the body by drip. After that, NK cells, NKT cells, and γδT cells will travel around the body and use their own methods to find cancer cells. Once the cancer cells are confirmed, they will attack the cancer cells.

 

Treatment process

JMT: Principles of Japanese immune cell therapy

1. Medical consultation

According to the patient’s “cancer information” (blood tests, diagnostic images, etc.) and in order to understand the factors that may affect treatment, medical-related information including “patient information” (current physical problems, work, lifestyle, family), etc., from including Many medical resources, including standard treatment, discuss with patients to provide patients with the best treatment plan.

2. First inspection

When choosing active NK/NKT/γδT cell therapy, check tumor index and infection first

3. Blood draw and injection

Repeated intravenous blood draw and drip infusion once every 2 weeks. (One course of treatment is 6 times of intravenous infusion).

4. Evaluation of treatment

After a course of treatment, QOL (Quality of Life) is immediately evaluated, and treatment is evaluated based on immune profile analysis test or tumor index and imaging diagnosis.

In addition, three months after the end of a course of treatment, QOL (Quality of Life) was evaluated again, and treatment was evaluated based on immune profile analysis test, tumor index and imaging diagnosis, and future plans were discussed with the patient.

Side effects

Because it uses the patient’s own immune cells and immune system, there are few side effects.

In a small number of people, the strong immune response within a few hours after the injection may cause chills or fever of 37-38 degrees, but it will subside in about half a day. In addition, the injection site may be red and swollen, but it will disappear in about one night.

Adaptation to diseases and conditions

  • Cancer (various stages of cancer)
  • Prevent cancer, prevent recurrence
  • Anti-Aging

 

(sourceinternet, reference only)


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