April 16, 2024

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What is the difference between Atorvastatin and Rosuvastatin? 

What is the difference between Atorvastatin and Rosuvastatin? 


What is the difference between Atorvastatin and Rosuvastatin?   Antihypertensive drugs are only part of the blood pressure reduction.

In fact, for most people, there is no essential difference between atorvastatin and rosuvastatin. Both of these statins belong to the latest statins, and they are both third-generation statins, which have a strong lipid-lowering effect and can be used. Take it during the day and night.

They are all good medicines, but they all have side effects. If they are used correctly, they can cause illness. There is still a slight difference. Let’s compare atorvastatin and rosuvastatin today, and look at the two masters today:

1.  Lipid-lowering effect

The first task of statins is of course to lower cholesterol and low-density lipoprotein, so we must first compare the lipid-lowering effect. In fact, statins also have the effect of raising high-density lipoprotein.

At the same recommended dose, we generally recommend 10 mg of rosuvastatin in our regular dose and 20 mg of atorvastatin, both of which can reduce low-density lipoprotein by 30%-40%. From this point of view, atorvastatin and rosuvastatin are equivalent.

2.  Stabilizer reverses plaque

Plaque rupture will cause thrombus formation, cerebral infarction and myocardial infarction. At the recommended dose,  20 mg of atorvastatin and 10 mg of rosuvastatin, both are significantly stable. Rosuvastatin is slightly better than atorvastatin. .

Studies have found that high-dose statins can indeed reverse plaques in some people, that is, reduce plaques, but increasing the dose of statins will increase the risk of statin side effects.

Therefore, it is not recommended to reverse plaques for individual individuals. Increase the statin dose. The two statins match each other.  Rosuvastatin is slightly better than atorvastatin, almost equivalent.

3.  Anti-inflammatory

Atherosclerosis can cause vascular stenosis, which is a cause of cardiovascular and cerebrovascular diseases. Another cause of cardiovascular and cerebrovascular diseases is inflammation.

Inflammation in blood vessels can cause cardiovascular and cerebrovascular diseases, so anti-inflammatory is very important. In terms of anti-inflammatory function, atorvastatin and rosuvastatin are no different.

4.  Myotoxicity

All statins have potential muscle toxicity. Even if it only occurs in a small number of people, we should also pay attention to it. If bleeding and muscle pain during the period of taking statins, you need to see a doctor immediately.

Even if there are no symptoms, you need to review muscle enzymes regularly. It is generally recommended It is found that muscle enzymes have increased by 10 times and the drug needs to be discontinued, but we usually find problems in time to reduce the drug or stop the drug for observation.

A large amount of data shows that rosuvastatin is relatively more likely to cause muscle damage in terms of muscle toxicity.

Rosuvastatin is worse than atorvastatin, which is relatively safer.

Atorvastatin is superior to rosuvastatin.

But there is no absolutely safe statin, and side effects need to be monitored.

5. Liver Toxicity

Another common side effect of all statins is liver toxicity, but it only occurs in a small number of patients, and once the transaminase rises and the drug is stopped, the liver function can return to normal, and there is no need to stop the drug if the transaminase is within 3 times.

Atorvastatin is a lipophilic statin, and its metabolism mainly occurs in the liver, which has a relatively large impact on the liver; rosuvastatin is a hydrophilic statin that has a small impact on the liver. (Yellow people are relatively more prone to liver damage.)

6. Kidney Toxicity

Many studies have shown that atorvastatin has basically no effect on the kidneys, so in this respect, rosuvastatin is slightly worse than atorvastatin.

7.  The impact on the metabolism of other drugs

Atorvastatin undergoes 3A4 metabolism and may compete with some antibiotics, including the controversy about not being able to eat grapefruit.

Therefore, during the period of taking atorvastatin, try to eat less fruits such as grapefruit and avoid taking erythromycin and clarithromycin.

The mutual influence of rosuvastatin and other drugs is relatively less than that of atorvastatin.

Rosuvastatin is superior to atorvastatin.

In short, again, there is no absolutely safe drug, and there is no absolutely safe statin.

Both atorvastatin and rosuvastatin need to be taken under the guidance of a specialist, and the side effects of the drug need to be monitored for a long time to play a role.

The drug has the greatest effect and reduces the side effects of the drug.


(source:internet, reference only)

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