June 29, 2022

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Combined cold and heat ablation for advanced pancreatic cancer

Combined cold and heat ablation for advanced pancreatic cancer

 

Combined cold and heat ablation for advanced pancreatic cancer.  Combined cold and heat ablation can be selected if too late for surgery. 


For resectable pancreatic cancer, radical resection + postoperative adjuvant chemotherapy is the current first-line treatment. But for unresectable pancreatic cancer, the effect of direct chemotherapy is not satisfactory, mainly due to the untreated primary tumor.

The “cold and hot composite ablation technology” is based on freezing and ablation and then heating up, melting the ice ball formed at a very low temperature and raising it to a high temperature of 80 ℃, so that the rapid freezing and then rapid rewarming two cycles.

The advantage of the combination of cold and heat ablation technology is that the ultra-wide temperature difference can directly kill tumor cells, which can not only completely necrosis and inactivate the tumor, but also protect the surrounding tissues from side damage, achieving an efficient and safe tumor killing effect.

At the same time, the high temperature of 80°C during the rewarming stage caused coagulation and necrosis around the probe, effectively reducing the risk of needle bleeding, pancreatic fistula and tumor residual. 

At present, all aspects related to new technology such as surgery, ultrasound, anesthesia, perioperative management and nursing are unified and standardized to form standards.

 

Advantages of indirect killing and immune killing of the cold and heat compound ablation technology:

Indirect killing:

Indirect killing refers to the combination of cold and heat ablation that can damage and embolize the nourishing blood vessels around the tumor, cut off the blood supply of the tumor, and make the tumor lose its source of nutrition, thereby indirectly killing the tumor cells.

Immune killing:

Immune killing refers to the cell rupture caused by the combination of cold and heat ablation that can release the microstructures in tumor cells. These microstructures carry the characteristics of tumor cells and are specific antigens. They activate the body’s immune response and produce a large amount of The killing immune cells directed against the tumor further exert a systemic and sustained anti-tumor effect through the immune killing effect.

 

So, which patients are suitable for combined cold and heat ablation treatment?

1. Locally advanced (stage Ⅲ) pancreatic cancer that cannot undergo radical surgery;

2. Advanced (stage IV) pancreatic cancer with oligometastasis in the liver;

3. Local mid-late or metastatic pancreatic neuroendocrine tumors;

4. Residual pancreatic cancer: patients with pancreatic cancer who have undergone resection of the head of the pancreas or the body and tail of the pancreas;

5. Pancreatic metastases: Tumors from other parts of the body directly invade or metastasize to the pancreas, and cannot be resected, but there is no distant metastasis;

6. The imaging assessment is that the pancreatic tumor can be removed, but the patient is unwilling to operate or the general condition is poor and cannot tolerate radical resection

 

(source:internet, reference only)


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