June 29, 2022

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Stem cells will cure Hashimoto’s thyroiditis?

Stem cells will cure Hashimoto’s thyroiditis?

 

Stem cells will cure Hashimoto’s thyroiditis?


Stem cells have a good immunomodulatory effect, which makes them have a good application prospect in the treatment of thyroid dysfunction.


Hashimoto’s thyroiditis is related to abnormalities in the body’s immune system. It is mainly due to the presence of autoantibodies that attack the thyroid in human blood. There are also a variety of cytokines and complements that induce apoptosis.

These components attack thyroid cells and cause the body’s Thyroid follicles are damaged by different degrees of inflammation, which affects the secretion and release of thyroid hormones, which leads to physical discomfort in patients.

 

Clinical epidemiological studies have found that the prevalence of Hashimoto’s thyroiditis is about 1% to 2%, and the incidence of women is significantly higher than that of men, and most of them are middle-aged people in their 40s and 50s.

It is currently believed that the occurrence of the disease is closely related to heredity, high iodine intake, viral infection, radiation, and mental factors.

 

Treatment of Hashimoto’s Adenitis

Early diagnosis of Hashimoto’s thyroiditis is very important. Traditional Western medicine treatment methods are limited, mainly through hormone replacement therapy to improve symptoms. Many patients still have many symptoms after normal thyroid function. This is related to autoimmunity and also related to the cause of Hashimoto’s thyroiditis.

For example, the detoxification function of the liver is reduced, and the adrenal cortex function is reduced by stress. Therefore, in addition to alternative treatments, the treatment of Hashimoto’s thyroiditis may require related prevention or treatment for the induced cause.

 

Stem cells and autoimmune diseases

As we all know, most autoimmune diseases are refractory diseases, and the existing treatment methods for these diseases can only control the progression of the disease or relieve the symptoms, and basically cannot cure them. But it is this hard bone that leaves stem cells the opportunity to shine.

 

In recent years, with the development of stem cells and regenerative medicine, stem cells, known as “universal cells” by the medical community, have begun to show their talents in the treatment of refractory diseases. Similarly, stem cells with unique skills in the treatment of autoimmune diseases are triumphant and have broad clinical application prospects.

 

Stem cells will cure Hashimoto's thyroiditis?

 

 

Treatment of Hashimoto’s Adenitis

Published research results in “Autoimmunity” magazine: Stem cells can improve Hashimoto’s thyroiditis in rats by regulating the balance of Th17/Treg cells.

 

In this study, researchers used 24 female Hashimoto’s thyroiditis SD Hashimoto’s thyroiditis rats to establish HT model rats, and evaluated the transplanted stem cells to regulate bridges in the rat Hashimoto’s thyroiditis (HT) model system. Ben’s thyroiditis Th17 Hashimoto’s thyroiditis/Hashimoto’s thyroiditis Treg Hashimoto’s thyroiditis ability to interact.

 

The research team was surprised to find that, compared with the HT Hashimoto’s thyroiditis model rats, the transplanted stem cells can reduce the thyroid lesions in the rats. Compared with the HT model rats, the thyroid tissue integrity is higher and the lymphoid infiltration of the thyroid gland is reduced.

 

The author stated that Th17/Treg imbalance is related to the development of a variety of immune-related diseases. This imbalance can lead to autoimmune diseases. The balance of Th17 and Treg cells is of great significance for regulating the pathogenesis of HT and improving disease development.

 

 

Stem cells have a good immunomodulatory effect, which makes them have good application prospects in the treatment of thyroid dysfunction.

Stem cells can inhibit the proliferation of T cells and B cells to achieve the clinical effect of regulating the body’s own immune response, and this immunomodulatory effect Unlike the single-molecule regulation of immunosuppressants commonly used in clinical practice, stem cells are achieved through multi-molecule participation, multi-channel regulation and their paracrine effects, which can effectively repair damaged thyroid gland, restore function, and improve symptoms of hypothyroidism.

 

The immunomodulatory function of stem cells interacts with the microenvironment of body inflammation.

A higher content of pro-inflammatory factors in the inflammatory microenvironment will prompt stem cells to secrete more anti-inflammatory cytokines; conversely, the content of pro-inflammatory factors in the microenvironment When it decreases, the secretion of anti-inflammatory factors from stem cells will decrease.

According to the characteristics of stem cells, scientists pretreat stem cells with microenvironment such as hypoxia, high glucose, inflammation, etc., to increase the expression of anti-inflammatory factors of stem cells, and then to exert anti-inflammatory effects more effectively.

Stem cells interact with the body’s inflammatory microenvironment and dynamically regulate the body’s immune response, which will help the body avoid systemic infections caused by immunosuppressive agents commonly used in clinical practice.

 

 

 

 

Stem cells will cure Hashimoto’s thyroiditis?

(source:internet, reference only)


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