- ‘Cancer-Shattering’ Method Targets Non-Coding Sequences to Eradicate Brain Tumors
- What is HIV Post-Exposure Prophylaxis (PEP)?
- Moderna Team Detects No Uptake of mRNA-LNPs in Muscles at Injection Site
- Vitamin B5 Found to Promote Cancer Growth
- Harmful Chemical D5 Found in Common Hair Care Products
- Antibiotics Unveiled as Potential Life Extenders Aiding Healthier Aging
What are the health impacts of PFAS?
- FDA Investigates T-Cell Malignancy Risk in CAR-T Cell Therapy
- WHO Requests More Information from China on Pediatric Clustered Pneumonia
- First Chinese PD-1 Cancer Drug 30 Times More Expensive in U.S. than in China
- Cardiovascular Diseases Linked to COVID-19 Infections
- What is the difference between dopamine and dobutamine?
- How long can the patient live after heart stent surgery?
Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that have been associated with a range of health impacts.
They are known for their ability to repel water, oil, and stains, which makes them useful in various applications.
The extent and severity of these impacts can vary depending on the specific PFAS compound, the level of exposure, and individual factors.
While PFAS offer practical benefits in these applications, they have raised concerns due to their persistence in the environment and potential health effects.
PFAS are often called “forever chemicals” because they do not break down easily and can accumulate in the environment and in the human body over time.
Exposure to certain PFAS compounds has been associated with health risks, including potential links to cancer, liver damage, immune system suppression, and other health issues.
Some of the health impacts associated with PFAS exposure include:
Cancer: Some PFAS compounds have been linked to an increased risk of cancer, particularly kidney cancer, testicular cancer, and non-Hodgkin lymphoma.
Liver Damage: PFAS exposure can lead to liver damage, including liver inflammation and fatty liver disease. Severe liver damage can have long-term health consequences.
Immune System Effects: PFAS exposure can suppress the immune system, making individuals more susceptible to infections and impairing the body’s ability to fight diseases.
Endocrine Disruption: Some PFAS compounds can disrupt the endocrine system and interfere with hormone regulation, potentially leading to hormone-related health issues.
Reproductive and Developmental Effects: Prenatal exposure to PFAS may lead to low birth weight, preterm birth, and developmental delays in children. PFAS exposure may also affect fertility in both males and females.
Cardiovascular Effects: Some studies suggest that PFAS exposure may be associated with an increased risk of cardiovascular diseases, such as high blood pressure and heart disease.
Kidney Function: PFAS exposure has been linked to decreased kidney function, which can have serious health implications.
Thyroid Function: PFAS can affect thyroid hormone levels, potentially leading to thyroid disorders.
Cholesterol Levels: Some PFAS compounds can increase levels of cholesterol and triglycerides in the blood, which are risk factors for cardiovascular diseases.
Neurological Effects: There is emerging research on potential links between PFAS exposure and neurological effects, including cognitive and behavioral impacts.
Gastrointestinal Issues: PFAS exposure may lead to gastrointestinal problems, including colitis and changes in gut microbiota.
It’s important to note that the health impacts of PFAS can depend on factors such as the duration and level of exposure.
In many cases, the health effects of long-term exposure to relatively low levels of PFAS are of greater concern.
Because of these potential health risks, there are ongoing efforts to regulate and reduce PFAS contamination in the environment and to limit human exposure to these chemicals.
If you suspect PFAS exposure or are concerned about its health effects, it is advisable to consult with a healthcare professional for guidance and testing if necessary.
Why are PFAS considered carcinogens?
PFAS (per- and polyfluoroalkyl substances) are considered potential carcinogens or substances that may cause cancer due to the following reasons:
Epidemiological Studies: Some epidemiological studies have found associations between PFAS exposure and an increased risk of certain cancers. For example, studies have suggested potential links between PFAS exposure and kidney cancer, testicular cancer, and non-Hodgkin lymphoma, among others.
Animal Studies: Animal studies involving exposure to certain PFAS compounds have demonstrated an increased incidence of tumors, particularly in the liver, pancreas, and testes. These findings raise concerns about the potential carcinogenicity of some PFAS chemicals.
Mechanistic Studies: Research has shown that PFAS compounds can induce various cellular and molecular changes that are associated with cancer development. These changes can include DNA damage, disruption of hormone regulation, inflammation, and alterations in gene expression, all of which are known to be involved in cancer processes.
Regulatory Agencies: Several regulatory agencies, including the U.S. Environmental Protection Agency (EPA) and the International Agency for Research on Cancer (IARC), have classified specific PFAS compounds as potential or possible carcinogens. For example, perfluorooctanoic acid (PFOA) has been classified as “possibly carcinogenic to humans” by IARC.
It’s important to note that the potential carcinogenicity of PFAS can vary depending on the specific compound and its chemical structure.
Not all PFAS chemicals are necessarily carcinogenic, and more research is needed to better understand the specific mechanisms and risks associated with individual PFAS compounds.
Nevertheless, due to the existing evidence of potential carcinogenicity, there is ongoing concern about the health risks associated with PFAS exposure, and efforts are being made to reduce environmental contamination and human exposure to these substances.
What kind of PFAS strongly causes cancer?
There isn’t a single PFAS (per- and polyfluoroalkyl substances) compound that is universally recognized as strongly causing cancer. The potential carcinogenicity of specific PFAS compounds can vary, and research on this topic is ongoing.
However, some PFAS compounds have been more closely studied in relation to cancer risk, and their associations with cancer have been noted in certain studies.
Two of the more extensively studied PFAS compounds in this regard are:
Perfluorooctanoic Acid (PFOA or C8): PFOA has been one of the most studied PFAS compounds in relation to cancer risk. Research has suggested potential links between PFOA exposure and various cancers, including kidney cancer, testicular cancer, and non-Hodgkin lymphoma.
Perfluorooctanesulfonic Acid (PFOS): PFOS is another PFAS compound that has been associated with a potential increased risk of cancer, particularly in animal studies.
It’s essential to note that while these associations have been observed in some studies, the overall evidence on PFAS and cancer is still evolving, and more research is needed to establish definitive causal links.
Additionally, the specific health effects of PFAS can depend on factors such as the level and duration of exposure, individual susceptibility, and the specific chemical structures of the PFAS compounds.
Regulatory agencies like the U.S. Environmental Protection Agency (EPA) and the International Agency for Research on Cancer (IARC) have classified certain PFAS compounds as potential or possible carcinogens, emphasizing the need for ongoing research and risk assessment.
Because of these concerns, many countries and regions have implemented restrictions and regulations on the use of certain PFAS compounds, and efforts are being made to reduce environmental contamination and human exposure to these chemicals.
If you have concerns about PFAS exposure and cancer risk, it’s advisable to consult with healthcare professionals and stay informed about the latest scientific findings and regulatory measures.
What are the health impacts of PFAS?
(source:internet, reference only)