February 22, 2024

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Cell Therapy for Tumors: The Significance of NKM Cells

Cell Therapy for Tumors: The Significance of NKM Cells



Cell Therapy for Tumors: The Significance of NKM Cells

A groundbreaking research is published in the AGING journal titled “Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells.”

Cell Therapy for Tumors: The Significance of NKM Cells

This marks Boao Lecheng’s inaugural public document on cell applications, focusing on the immunoregulatory effects of NKM cells in addressing suboptimal health and supporting cancer patients.

The article emphasizes the crucial role of the immune system as a primary defense against diseases, influenced by various factors such as genetics and age. The imbalance of immune cell responsiveness can lead to diseases like cancer, while excessive activation can result in autoimmune disorders, highlighting the importance of immune system balance for overall health.

Professor Chen Lieping and colleagues propose the concept of “immune normalization” in cancer treatment, suggesting that restoring immune function can prevent various diseases. The last decade has seen significant progress in cell therapy, particularly those utilizing immune cells, such as natural killer (NK) cells and chimeric antigen receptor T (CAR-T) cells, in cancer treatment.

Today, let’s delve into the NKM cell therapy and understand its significance.

1. What are NK Cells?

NK cells, residing in the bloodstream, play a vital role in immune response, hematopoiesis, and clotting, with a primary focus on tumor resistance, antiviral activities, and immune regulation. They are recognized as the first line of defense in the medical community, exhibiting stronger and more effective abilities to eliminate tumor and virus-infected cells compared to other anticancer immune cells.

2. What are NKM Cells?

NKM cells refer to natural killer immune cells, encompassing NK cells and other immune cells such as T cells, B cells, and dendritic cells. These cells are essential components of the immune system, resisting viruses, producing a wide array of antibodies, and collectively regulating immune system function.

3. What is NKM Cell Therapy Technology?

NKM cell therapy involves utilizing autologous cultivation of NKM cells to enhance immune function, considered a safer and more effective method for cancer prevention and treatment. The use of PD-1 and CTLA-4 antibody drugs at the ODA Clinic in Japan further activates NK cells, increasing their activity to over 90%. Combined with a certain proportion of T cells and other immune cells, NKM cell therapy proves to be safer and more effective than NK cell therapy alone.

4. Suitable Candidates for NK Cell Therapy

  1. Individuals with a family history of cancer or in good health seeking immune system enhancement for disease prevention and improved quality of life.
  2. Cancer patients undergoing complementary treatment to boost resistance, eliminate cancer tissues, and reduce treatment side effects.
  3. Individuals with a history of cancer aiming to prevent recurrence.

5. Clinical Effects

  • NKM cell therapy demonstrates broad applicability for various tumors, including lung, breast, stomach, colorectal, liver, and prostate cancers, as well as hematologic malignancies and lymphomas.
  • After surgery or radiotherapy, NKM immune cell therapy clears residual tumor cells, preventing recurrence and metastasis.
  • Intermittent use during chemotherapy effectively reduces toxic side effects and increases drug sensitivity.
  • In cases of extensive tumor metastasis where surgery is not possible, NKM cell therapy, in conjunction with radiation and chemotherapy, achieves optimal treatment results.
  • For tumors insensitive or intolerant to traditional treatments, NKM cell therapy alone can enhance the quality of life.

In summary, NKM cell therapy directly targets tumor cells, activates T cells to kill tumors, induces B cells to release antibodies, and promotes dendritic cell maturation for specific immune responses.

Cell Therapy for Tumors: The Significance of NKM Cells


(source:internet, reference only)

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