Stem cell treatment for hair loss and hair regrowth are effective

Stem cell treatment for hair loss and hair regrowth are effective. The ability of stem cells to promote hair regeneration after pretreatment is greatly enhanced.

Hair loss is a common and troublesome problem. It is caused by a series of complex reasons including genes, hormones, trauma and iatrogenic events. In China alone, about 160 million people suffer from hair loss. There are currently several treatment options for patients with hair loss, such as oral or topical medications, or surgical treatment. However, these treatments have limitations. Medication can only relieve symptoms for a short period of time. When the patient stops taking the medication, the hair will begin to fall out.

For example, oral finasteride has sexual side effects and can be deformed. After stopping the medication, hair loss will accelerate. The use of autologous single hair follicle and follicular unit transplantation is a reliable surgical treatment method, but the number of hair follicle donors is limited, and the survival rate of hair follicle transplantation is low, the cost is high, and it will bring great pain to the patient. Therefore, hair loss urgently needs some new treatments. A large number of studies have found that stem cells have significant effects on hair regeneration and prevention of hair loss, which brings dawn and hope to patients with hair loss.

Hair loss is an inflammatory cytokine-mediated disease. The pathogenesis of hair loss is closely related to the signal transduction mediated by Th-1 and NKG2D. Studies have shown that hair follicles are immune exempt parts. When the immune exemption of hair follicles collapses, CD4 and CD8 T cells and some natural killer cells gather around the hair bulb self-antigens and cause hair loss. Mesenchymal stem cells have cellular immune regulation and anti-inflammatory effects. Ji and his colleagues injected the stem cells intravenously into depilated rats and found that the stem cells can inhibit the production of IFNG, CXCL9 and CXCL10 and NKG2D+T cells The penetration can effectively prevent hair loss.

Stem cells can secrete a large number of growth factors, such as keratinocyte growth factor, vascular epithelial cell growth factor, platelet growth factor and hepatocyte growth factor. These growth factor proteins play an important role in promoting hair regeneration. The latest Korean experimental study found that stem cell conditioned medium is effective in treating female hair loss.

Shin injected the stem cell conditioned medium microneedle into the patient’s skin. After 12 weeks, the patient’s hair density and thickness increased significantly without any side effects. Fukuoka and Suga gave 22 hair loss patients subcutaneously injected stem cell conditioned medium. These patients received 6 courses of treatment, each course lasted 3-5 weeks. The results showed that the hair of male and female patients increased significantly.

The ability of stem cells to promote hair regeneration after pretreatment is greatly enhanced. Vitamin C, PDGF, hypoxia and UVB can all stimulate stem cells to enhance their value-added and promote hair regeneration potential. Fukuoka cultures stem cells under hypoxic conditions, collects stem cell conditioned medium, and adds cysteine, coenzyme Q10 and vitamins. Every 3-5 weeks, the 12 female patients and 13 male patients who received the treatment experienced a significant increase in hair by subcutaneous injection of 4-6 pretreated stem cell conditioned medium.

The above experimental research results show that stem cells and their conditioned medium can promote hair regeneration and prevent hair loss. Compared with hair follicle transplantation, stem cell treatment of hair loss has the advantages of convenience, safety, significant effect, simple treatment process, and high patient acceptance, which brings an alternative treatment method for hair loss patients.

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