- High-frequency aspirin use is associated with a 13% reduction in ovarian cancer risk
- Why don’t all obese people get type 2 diabetes?
- Toxic PFAS chemicals make rainwater unsafe to drink around the world
- Scientists manage to extend the shelf life of vaccines
- Why do men face a higher risk of most types of cancer than women?
- Will your smartphone tell someone if you’ve been to an abortion clinic?
3 clinical application cases of stem cell anti-aging
3 clinical application cases of stem cell anti-aging. The investigation of 3 clinical cases confirmed the good effects of stem cells and cytokines in the field of anti-aging.
The aging population increases the burden of medical care, and stem cell anti-aging and repairing the accompanying dysfunction have become a new method in the field of treatment. Stem cells have the functions of regeneration and immune regulation, and can promote the regeneration and repair of aging tissues through directly differentiated cell replacement and cell empowerment.
In 2017, some countries issued the “Guidelines for the Standardization of Stem Cell Anti-aging Technology”, which put forward a series of requirements and specifications for stem cell anti-aging work, and promoted the clinical research and application of stem cell anti-aging. Stem cells and their cytokines have become a hot topic in anti-aging research in recent years, and have achieved good results in the field of facial anti-aging.
1. Stem cell therapy
①Human umbilical cord mesenchymal stem cells (hUCMSCs)
hUCMSCs is a kind of stromal cells isolated from umbilical cord Wharton glue. It has rich sources, high proliferation rate, self-renewal and multidirectional differentiation potential, and also has strong repair and regeneration capabilities, low immunogenicity, and biological safety. high.
hUCMSCs inhibit the secretion of inflammatory factors during skin injury, promote the release of anti-inflammatory mediators, and improve the local microenvironment of the injury; the VEGF factor secreted by stem cells activates the Notch signaling pathway, thereby promoting the formation of new cells and blood vessels, and has an anti-aging effect.
Clinical case 1: 143 patients with stage III and IV pressure ulcers were treated with epidermal growth factor therapy (55 cases), conventional therapy (30 cases), and epidermal growth factor combined with hUCMSCs transplantation (58 cases). The results showed that epidermal growth factor combined The hUCMSCs transplantation effect is more obvious, the wound healing is accelerated, and the tissue infection is reduced.
②Adipose Mesenchymal Stem Cells (ADSC)
ADSCs are adult mesenchymal stem cells derived from the mesoderm that can induce multidirectional differentiation into different cells, tissues and organs. ADSC is convenient to obtain materials, rarely expresses or even does not express the type II major histocompatibility complex, almost no immune rejection, suitable for autologous transplantation.
Clinical case 2: The researchers injected autologous adipose stem cells into the facial depressions and cheek depressions in 100 patients who received facial soft tissue contouring in the burn department. Observation and follow-up for 12 months showed that 93 cases of facial were significantly improved and effectively improved In 7 cases, the skin thickness of most patients increased, dermal collagen fibers increased, spots decreased, and the skin became delicate and shiny. The treatment satisfaction rate was 95%.
2. Stem cell factor
Stem cells can secrete a variety of biologically active substances, including epidermal growth factor (EGF), fibroblast growth factors (FCFs), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF), platelet-derived growth factor (PDGF), etc. , Can improve the body’s ability to resist free radicals and regulate the body’s state.
Clinical case 3: A large number of growth factors secreted by adipose-derived mesenchymal stem cells, such as KGF, PDGF, etc., can stimulate more hair follicles to enter the growth phase, improve hair loss, and promote hair regeneration. Fukuoka et al. injected adipose-derived mesenchymal stem cell conditioned medium into the scalp of 22 patients with alopecia. After 6 months, the number of patients’ hair increased significantly; Shin et al. used adipose-derived mesenchymal stem cell conditioned medium to treat alopecia patients in a clinical trial, Significant effect.
The investigation of 3 clinical cases confirmed the good effects of stem cells and cytokines in the field of anti-aging, which are expected to be widely studied and applied.
(sourceinternet, reference only)