May 28, 2024

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Why are cancer cells resistant?

Why are cancer cells resistant?

Why are cancer cells resistant?  Faced with the drug resistance of cancer cells, are we really helpless?

Cancer cell resistance is a headache for countless cancer patients and doctors. This means that cancer cells may spread uncontrollably, which is an important cause of cancer metastasis or recurrence!


As canner cells are reistant, are we really helpless?

Recently, Dr. O’Brien, a scientist at the Princess Garrett Cancer Center in the United States, has made a new discovery: When the outside world carries out a “powerful offensive” of chemotherapy on the human body, cancer cells will enter a slow-dividing state after feeling threatened state), this state can help cancer cells survive the harsh environment caused by chemotherapy, that is, drug resistance.

This research was published in the Cell magazine, and the research results will provide new ideas for overcoming the drug resistance of cancer cells.

Cancer cells “hibernate”-develop drug resistance

The researchers treated human colorectal cancer cells in a petri dish with chemotherapy. These colorectal cancer cells “attacked” by chemotherapy will enter a slow dividing state that stops proliferating. In this state, even if there is no nutrient supply, they can still survive.

The researchers also found that as long as the chemotherapy treatment is continued in the petri dish, the cancer cells can remain in this state. Once the chemotherapy treatment is stopped, the cancer cells will proliferate rapidly again.

Why are cancer cells resistant?

It is as if animals enter a hibernation state in the harsh winter, “go through” the “difficult phase” very low-key, and wait for the spring flowers to “come back”!

Cancer cell “autophagy”-overcoming drug resistance

So, can cancer cells enter a “hibernation” state and no longer recover? Fortunately, researchers have found an anti-cancer strategy for this resistance based on this phenomenon.

In order to survive without other nutrients, “hibernating” cancer cells will turn on the “autophagy” mode, that is, destroying their own proteins or other cellular components to support themselves. Researchers speculate: If effective measures are taken to block the “autophagy” of cancer cells, will they destroy the drug resistance of cancer cells, thereby avoiding cancer recurrence and metastasis?

This hypothesis was confirmed in experiments. The researchers used a small molecule that inhibits autophagy on these hibernating cancer cells. Without nutrient supply, the cancer cells lost their protective mechanism and were quickly killed by chemotherapy drugs. Up!


This research provides a new idea for overcoming the drug resistance of cancer cells, that is, when cancer cells enter a fragile state of slow division, attacking them can prevent cancer cell gene mutations from developing drug resistance.


We hope that this discovery can provide new ideas and breakthroughs for cancer treatment, and achieve clinical applications in the near future to benefit cancer patients.


(source:internet, reference only)

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