PNAS: The molecular mechanism of immune cells driving tumorigenesis

PNAS: The molecular mechanism of immune cells driving tumorigenesis. Demystifying the molecular mechanism that immune cells are recruited and reprogrammed to drive tumorigenesis

A research report published in the international journal Proceedings of the National Academy of Sciences, scientists from Sweden’s Caroline Academy and other institutions revealed through research Immune cells—how macrophages are recruited into breast cancer tumors and are reprogrammed to support and drive tumor growth; researchers say that low levels of the tumor suppressor protein TAp73 may lead to hyperactivation of NFkB signaling and breast cancer The inflammatory state also promotes the secretion of special molecules, thereby recruiting tumor-promoting macrophages into breast tumors.

Breast cancer is a common cancer among women around the world, and understanding the pathogenesis of this complex disease is essential for the development of new therapies. Researcher Dr. Margareta Wilhelm said that previous research results have shown that the penetration of immune cells into tumors is very important for the occurrence and development of tumors. There is between the penetration of immune cells that attack tumor cells and immune cells that protect tumor cells and promote tumor growth and spread. A good balance mechanism.

Image source: Johanna Wolfsberger, et al. PNAS, doi: 10.1073/pnas.2017089118

In this study, the researchers found that the decrease in the level of protein TAp73 is related to more aggressive breast cancer. TAp73 may act as an inhibitor of NFkB activation. NFkB can activate a variety of functions in cells, including secreting inflammation. Chemokines are used to attract immune cells to tumor tissues. The down-regulation or deletion of TAp73 will cause NFkB to be hyperactivated, and will up-regulate the secretion of the inflammatory chemokine CCL2. CCL2 can attract circulating monocytes to the tumor site, and then differentiate into special types of macrophages. To support tumor growth and lead to more aggressive cancers.

Finally, the researchers pointed out that this study increases scientists’ understanding of the mechanisms that drive breast cancer. At the same time, researchers have identified TAp7 as an important factor to regulate the process and mechanism of immune cell recruitment into tumors.

(source:internet, reference only)

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