August 11, 2022

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First study of vaccine neutralization activity against the Indian mutant strains

COVID-19 First study of vaccine neutralization activity against the Indian mutant strains

 

First study of vaccine neutralization activity against the Indian mutant strains.  The first study of vaccine neutralization activity against the live virus of India mutant strain was announced; compared with other mutant strains. 

On May 10, another important data preprint of an important Indian mutant strain B.1.617 was released.

The Mehul Suthar group of Emory University in the United States uploaded an important data on bioRxiv. For the first time, the neutralization test FRNT50 of the live virus of the Indian mutant strain B.1.617 was used to evaluate the neutralization of the serum of recovered patients, mRNA-1273 and BNT162b2 vaccinators. active.

The study found that the serum FRNT50 of the recovered patients dropped from 514 against the standard strain WA1 to 79 against the B.1.617 live virus, a 6.5-fold decrease.

Moderna’s mRNA-1273 vaccinators’ serum decreased 7 times from 1332 for WA1 to 190 for B.1.617.

The serum of Pfizer’s BNT162b2 vaccinators decreased 7 times from 1176 for WA1 to 164 for B.1.617.

First study of vaccine neutralization activity against the Indian mutant strains
(Neutralizing activity against India mutant)

However, the study found that the sera of the two kinds of mRNA vaccination patients still had significant neutralizing activity to B.1.617; most of the serum samples of the recovered patients had neutralizing activity to B.1.617.

 

Comparison of India mutant strains and other mutant strains

If we want to see more clearly how “powerful” the Indian mutant strain is, we can compare it with the research on other mutant strains.

On March 25, 2021, South African scientists published an article in the New England Journal of Medicine (NEJM), summarizing the characteristics of the current three major variants of the new coronavirus and the protection of the current seven major vaccines.

Moderna’s mRNA-1273 vaccinated serum had a 2-fold decrease in neutralizing activity against British mutants, a 6.7-fold decrease against Brazilian mutants, and a 6.5-fold decrease against South African mutants; (in contrast, a 7-fold decrease against Indian mutants).

The neutralizing activity of Pfizer’s BNT162b2 inoculated sera decreased 1.8 times against the British mutant, 4.5 times against the Brazilian mutant, and 8.6 times against the South African mutant; (compared to the Indian mutant, it decreased by 7 times).

Of course, it should be noted that the neutralization activity of different vaccine recipients is significantly different; the mRNA vaccine performs best.

First study of vaccine neutralization activity against the Indian mutant strains
(Neutralizing activity against other strains)

In the constructed fake virus experiment, we can also make another comparison.

On May 1, 2021, the Gupta group of the University of Cambridge in the UK uploaded data on the extremely important Indian mutant strain B.1.617 on Twitter and evaluated the escape of B.1.617. This is the first B.1.617 serological data. .

First study of vaccine neutralization activity against the Indian mutant strains
(Neutralizing activity against India mutant pseudovirus)

The results showed that the neutralizing activity of Pfizer mRNA vaccine BNT162b2 vaccinators for E484Q mutation decreased by 6 times, and the neutralizing activity for L452R decreased by 4 times; but the neutralizing activity of E484Q and L452R “double mutations” only decreased by 4 times.

Compare with other mutant strains.

On March 12, 2021, Cell magazine published an article by the Ragon Institute and the Balazs group of MGH. This study is currently the most comprehensive one to evaluate the changes in serum neutralization activity against various SARS-CoV-2 mutant strains after mRNA vaccination. Research.

The study found that the neutralizing activity of BNT162b2 on B.1.1.7 was reduced by 2.1 times, P.1 was reduced by 6.7 times, and B.1.351 was reduced by 34.5-42.4 times.

The neutralizing activity of mRNA-1273 on B.1.1.7 was reduced by 2.3 times, P.1 was reduced by 4.5 times, and B.1.351 was reduced by 19.2-27.7 times.


(Neutralizing activity against other mutant pseudoviruses)

Editor’s note:

Faced with the propaganda everywhere calling the Indian mutant strain the “Poison King”, we certainly cannot agree. because:
No data, unscientific.

Two newly published studies show that the Indian mutant strain is far from being the “poison king”:

1. The Indian mutant strain does reduce the neutralizing activity of the sera of mRNA vaccine recipients, but the vaccine is still effective.

2. Compared with other mutant strains, Indian mutant strains did not reduce the neutralizing activity of vaccine vaccinators more severely; however, since there is no research report on the same laboratory including the detection of Indian mutant strains at the same time, the comparison results are for reference only. .

Careful friends may see that we used a lot of “finally” when reporting the epidemic in India.

The ignorance of the epidemic in India led to the outbreak of the epidemic in India today.

Even in the face of a wild strain of the COVID-19 virus (the strain found in Wuhan for the first time), it will still cause a serious public health crisis. This situation has occurred in Wuhan, Italy, and New York; aren’t the medical conditions in these places much better than India? ? The new coronavirus does not require a more powerful mutant strain to cause serious harm.

In fact, the Indian mutant strain B.1.617 was discovered on October 5, 2020, and the Indian epidemic only began to break out in March 2021. The discovery of the Indian mutant strain was earlier than the other several mutant strains; however, no scholars have conducted research on this strain; because this strain is indeed easier to spread, but it is not more lethal.

More importantly, the Wuhan epidemic was the first outbreak of the COVID-19 virus, and humans were unprepared; while in India, countries around the world had considerable medical experience, and vaccines produced in India were available. This tragedy was not caused solely by the “Indian mutant” itself.

But what needs to be vigilant is that even though it is not the poison king, the Indian mutant strain is still not a waiter, and it is more contagious.

In addition, although the main cause of the Indian epidemic is not a mutant strain, it is more common for new and more terrifying mutant strains to appear in the outbreak area. This is a greater potential harm to India and the world. In fact, India’s second-generation mutant strains have become more terrifying. For details, see our introduction in another tweet today.

First study of vaccine neutralization activity against the Indian mutant strains

We also need to remain vigilant against the new coronavirus.

Because human beings may not be able to finally eliminate the new coronavirus completely, but can only control the pandemic of the new coronavirus; the possibility of seasonal or local epidemics of the new coronavirus in the future is getting higher and higher.

News on May 10: Novavax of the United States has developed a four-valent vaccine that combines influenza vaccine and COVID-19 vaccine. Therefore, we need adequate preparation.

 

(source:internet, reference only)


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