Someone in the family has lung cancer and your risk has soared!

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Someone in the family has lung cancer and your risk of lung cancer has soared!

Someone in the family has lung cancer and your risk has soared!  As the most common cancer, lung cancer is also the cancer that causes the most deaths. In 2018, 11.6% of the world’s new cancers were lung cancer, which is equivalent to 2.1 million people suffering from the disease. Only breast cancer is comparable.

At the same time, 18.4% of cancer deaths worldwide are due to lung cancer, equivalent to 176 Ten thousand people, twice as many as the second colorectal cancer [1].

Figure 1.1 Lung cancer is the real “king of cancer”

Figure 1.2 The incidence of lung cancer in East Asia is not low

There are many risk factors for lung cancer, the most important of which is smoking. At the same time, second-hand smoke, occupational exposure, air pollution, diet, history of respiratory diseases, and genetic susceptibility may also increase the risk of lung cancer.

Speaking of the heredity of cancer, people often think of breast cancer, but in fact, lung cancer also has a lot of genetic risks that you can’t get rid of. Previous studies have found that lung cancer in first-degree relatives is associated with an increased risk of lung cancer in other people in the family. Parents, siblings, and children with lung cancer may increase their lung cancer risk by half [3].

A recent study published in Lung Cancer [4] specifically assessed the relationship between the family history of lung cancer and lung cancer risk, and found that “one person has lung cancer, the whole family must be careful”-whether this is the gene to blame, or what should not be eaten of? Is it because the whole family loves to smoke, or is it bothered by second-hand smoke together? Let’s keep watching!

Figure 1.3 Research published in Lung Cancer

Gene: Relatives have lung cancer? The risk may rise by half!

This systematic review and meta-analysis from the Suriford School of Public Health, National University of Singapore included a total of 84 studies, including 19 cohort studies and 66 case-control studies; 50 studies came from European and American countries, and 35 studies came from In Asia, 22 of them are from China. In general, only 5 studies have found no relationship between family history of lung cancer and increased risk of lung cancer. The remaining >95% of the studies are telling you: If your relatives have lung cancer, you may also care about them besides visiting him. yourself!

Figure 2.1 The meta-analysis included 84 studies

Aggregating the results of all studies once again emphasized the finding that people with a family history of lung cancer may increase their risk of lung cancer by 85% (OR 1.85, 95% CI 1.71-1.99). The results of pooled cohort studies (OR 1.82, 95% CI 1.60-2.08) and case-control studies (OR 1.87, 95% CI 1.70-2.05) support this conclusion. It seems that I heard that someone in the family has lung cancer. Not only do you have to sweat for him, but also for yourself!

Asians seem to be more “loving each other” when it comes to lung cancer: Studies from Asian populations have found that someone in the family with lung cancer may mean that your lung cancer risk will double (OR 2.14, 95% CI 1.83-2.50), but in Western populations The increase in this risk was 73% (OR 1.74, 95% CI 1.58-1.89). However, the difference between men and women on this issue is not very large (OR 2.00, 95% CI 1.65-2.42; OR 2.05, 95% CI 1.78-2.35).

Who in the family is most dangerous to get lung cancer?

• If one parent gets lung cancer, your risk increases by 60% (OR 1.60, 95% CI 1.36-1.87);
• Dad gets lung cancer, the corresponding risk increases by 65% ​​(OR 1.65, 95% CI 1.50-1.81);
• The risk of mothers getting lung cancer increases by 69% (OR 1.69, 95% CI 1.22-2.33).
• Brothers and sisters get lung cancer, your risk increases by 78% (OR 1.78, 95% CI 1.57-2.03);
• Brothers get lung cancer, the corresponding risk increases by 39% (OR 1.39, 95% CI 1.11-1.74);
• For sisters with lung cancer, the corresponding risk increased by 93% (OR 1.93, 95% CI 1.29-2.87).
• And if your child has lung cancer, not only will you have to worry about whether he can cure the disease, but you will also find that your risk of lung cancer has almost doubled (OR 1.95, 95% CI 1.57-2.44).

The more people who have lung cancer in the family, the more likely the family is to get lung cancer: if one family member gets lung cancer, the risk of others will increase by 55% (OR 1.55, 95% CI 1.37-1.75), and 2 or more family members With lung cancer, the risk will soar to 2.72 times (OR 2.72, 95% CI 1.95-3.81).

The earlier lung cancer occurs, it may mean that the “seeds” of lung cancer at home are more likely to take root and sprout: If lung cancer is diagnosed in family members over 60 years old, the risk of lung cancer for others may not increase significantly (OR 1.47, 95%) CI 0.78-2.71), but if someone in the family is unfortunately diagnosed with lung cancer under the age of 60, then the whole family should be more vigilant (OR 1.85, 95% CI 1.03-3.31).

Figure 2.2 Family history of lung cancer means an 85% increase in risk

Figure 2.3 Both cohort studies and case-control studies found that family history increases the risk of lung cancer

Among Asian populations, women, young people, people who have never smoked, and people whose parents have lung cancer are at higher risk. Researchers believe that in addition to genetic factors, a family living together may also be affected by the same environmental factors. Especially in China, household air pollution caused by heating and cooking may cause a family to get lung cancer [5,6], and mothers who often cook may suffer even more. How can the risk of lung cancer be reduced by smoking oil fume[7]!

(source:internet, reference only)

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