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Cambridge University Research: Delta has the characteristics of rapid spread and vaccine resistance, but BNT162b2 is still highly effective against it
Delta variant of COVID-19 has rapid spread and vaccine resistance. According to the changes in the COVID-19 epidemic in the last two weeks, Dr. Fauci, the chief scientist of the US White House, concluded that “Delta mutant strains have become the main threat to the control of the COVID-19 epidemic.”
How serious is the Delta mutant strain, the second-generation mutant strain in India, in terms of infectiousness and resistance to vaccines? The Cambridge University Gupta group, which has made many contributions in the field of SARS-CoV-2 mutant strains, just made an answer.
On June 24, 2021, the group uploaded a blockbuster article on Research Square, pointing out that the Delta mutant strain not only has higher infectivity but also has more significant vaccine resistance properties. This finding confirms what many people have been worried about. , Delta has the characteristics of Alpha (B.1.1.7) that spreads quickly and Beta (B.1.351) that is resistant to vaccines.
The study analyzed the viral sequences of 100 medical workers who had a vaccine breakthrough infection in India, and found that the major strain of the breakthrough infection was Delta, and the viral load after the breakthrough infection was higher (Ct 16.5 vs. 19); and its transmission speed was significantly faster In Alpha and B.1.617.1 (p=0.02). In the in vitro test, compared with the wild type, the neutralizing activity of the vaccine-induced neutralizing serum for Delta was reduced by 8 times.
However, the neutralizing activity of the sera of BNT162b2 vaccinators against Delta is still higher, and it is significantly higher than that of AZD1222 vaccinators (GMT 3372 vs. 654, p<0.001).
This study pointed out that Delta has the characteristics of rapid spread and vaccine resistance, but BNT162b2 is still highly effective.
(source:internet, reference only)