October 5, 2022

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Two doses of COVID-19 vaccines still effective in preventing Delta variant

Lancet: Two doses of COVID-19 vaccines are still effective in preventing the Delta mutant strain, but the difference is very big…

 

 

Two doses of COVID-19 vaccines still effective in preventing Delta variant.  On June 28, 2021, The Lancet published a major UCL article, which attracted a lot of attention.

This article announced the neutralization and inhibition effectiveness of AstraZeneca vaccine AZD1222 and Pfizer/BioNTech vaccine BNT162b2 against the Delta mutant strain (B.1.617.2), and the conclusions of the study are critical.

The study found that after two inoculations with AZD1222, the neutralization titer NAbT IC50 of the inoculated sera against the wild-type was 419, which was 2.1 times lower than that of BNT162b2 after two inoculations; it was 2.4 times lower for the mutant strain D614G and for Alpha (B.1.1.7). , First reported in the UK) by 2.4 times, Beta (B.1.351, first reported in South Africa) by 2.5 times, and concerned Delta (B.1.617.2, first reported in India) by 2.5 times.

Studies have positioned the vaccine’s effective neutralizing antibody titer to be <40 as ineffective (no inhibitory effect); 40-256 as effective (inhibitory effect); >256 as efficient.

The study found that after two inoculations with AZD1222, 87% of the vaccinators were effective for Alpha, 60% were effective for Beta, and 62% were effective for Delta.

In contrast, 97% of subjects sera after two vaccinations with BNT162b2 are effective for Beta, while 95% are effective for Delta.


Seeing this result, and then looking at the current status quo in the three countries of the United Kingdom, the United States, and Israel, it seems a little bit that way. These three are the countries where the epidemic control situation after vaccination has once become a model, and the current differences are a bit big.

Almost all Israelis have received Pfizer vaccines, the United States has mostly received mRNA vaccines, and nearly half of them have received Pfizer vaccines in the United Kingdom.

However, it is also very likely that in 1-2 months, the United States and Israel will become the current Britain.

 

In any case, vaccination is always the key way to control the epidemic, but other non-drug treatment measures such as border management, wearing masks, and isolation measures are also very important.

Two doses of COVID-19 vaccines still effective in preventing Delta variant

 

(source:internet, reference only)


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