June 26, 2022

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Moderna COVID-19 vaccine: Effective against Delta variant for long-time

Moderna COVID-19 vaccine: Effective against Delta variant for long-time

 

 

Moderna COVID-19 vaccine: Effective against Delta variant for long-time.   Moderna’s COVID-19 vaccine can  produce a stable and long-lasting neutralizing antibody response, including the Delta mutant strain.

The Delta mutant strain has caused the global 9 primates in U.S. received experimental non-human COVID-19 vaccines epidemic to worsen again, and it raises a serious question:

Faced with mutant strains, Are the previously vaccinated vaccines still useful?

 

Moderna COVID-19 vaccine: Effective against Delta variant for long-time

On August 12, 2021, Science magazine published a blockbuster article from the National Institutes of Health (NIH) VRC, which immediately attracted a lot of attention.

This study found that even at 209 days after the first vaccination, the serum of mRNA-1273 vaccinators still had a high neutralizing activity (ID50>100) against the Delta mutant strain (B.1.617.2).

 

Moderna COVID-19 vaccine: Effective against Delta variant for long-time

(Neutralizing activity against various mutant strains. Source: Original Figure 1)

NIH VRC is the backbone of participating in Moderna vaccine development and clinical trials. This study evaluated the serum levels of mRNA-1273 7 months after vaccination against B.1.1.7 (Alpha), B.1.351 (Beta), P.1 ( Gamma), B.1.429 (Epsilon), B.1.526 (Iota) and B.1.617.2 (Delta) binding and neutralization levels.

Studies have found that only one vaccination cannot produce a cross-reactive broad-spectrum serum neutralization response, and after the second dose of vaccine, the serum produces a broad-spectrum neutralization response against all mutant strains.

Moderna COVID-19 vaccine: Effective against Delta variant for long-time(After 6 months, the positive rate of binding antibody; against the Delta mutant strain is still as high as 96%. Source: Original Figure 3)

And this serum neutralization lasts for more than 6 months. But the sera of vaccine recipients had the lowest antibody titers against Beta mutant strains (B.1.351).
This study pointed out that the neutralizing antibody response produced after mRNA-1273 vaccination is stable and long-lasting.

Reliable data is the basis for strategizing on the control of the epidemic.

From December 2021, the COVID-19 vaccine began to be vaccinated. By August 13, 2021, 4.6 billion doses of vaccine have been vaccinated globally; of which, China has received 1.82 billion doses of vaccine, accounting for 39%.

 


 

(source:internet, reference only)


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