The long-term sequelae of COVID-19 is actually a psychological effect?

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The long-term sequelae of COVID-19 is actually a psychological effect?

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The long-term sequelae of COVID-19 is actually a psychological effect?

Too much subversion has caused huge controversy: The latest research says that the long-term sequelae of the COVID-19 is actually a psychological effect?

Since the outbreak of the COVID-19 epidemic, it has continuously refreshed human’s understanding of the virus. As a “flying disaster” for the entire human race, the field and scope of its impact have also become larger and larger. Obviously, the COVID-19 pandemic has caused immeasurable losses to the world economy and profoundly affected the social order of mankind.

The receptor for the new coronavirus, ACE2, is a receptor protein widely distributed in the human body, mainly in organs and tissues such as the respiratory tract , intestines , kidneys , heart, and testes .

Many studies have pointed out that the new coronavirus infection will not only cause illness and death, but also cause other complications, and cause sequelae of different degrees and symptoms after the patient recovers. Common sequelae are: smell failure , fatigue, dyspnea, joint pain, chest pain and even depression .

On December 2, 2020, Nature published an article titled: Could COVID delirium bring on dementia? It pointed out [1] that the global pandemic of the COVID-19 has caused many patients to develop delirium , which may lead to global dementia several years later. The number of patients with disease has increased sharply.

On June 23, 2021, the top international medical journal Nature Medicine published a research paper titled: Long COVID in a prospective cohort of home-isolated patients [2] .

A survey of 312 patients with COVID-19 pneumonia in Norway found that more than half Young adults (16-30 years old) who are isolated at home with mild symptoms have long-lasting dyspnea, loss of taste and smell, fatigue, or inattention and memory loss six months after the initial infection .

August 28, 2021, top international medical journal ” The Lancet ” published an article entitled: 1-year Outcomes in Survivors Hospital with COVID-19: A Longitudinal Study cohort study papers, this by the Capital Medical University, Chinese medicine Researchers from the Academy of Sciences, China-Japan Friendship Hospital, and Jinyintan Hospital have jointly completed the largest sample of longitudinal cohort studies on the 1-year follow-up of discharged COVID-19 survivors, showing that the vast majority of discharged patients with COVID-19 pneumonia still have fatigue at least 1 year after their onset. One of the abnormal symptoms such as muscle weakness, sleep disturbance, hair loss, olfactory failure, heart palpitations, and joint pain .

These studies have reminded us that even after recovering from the new coronavirus , there may still be long-term sequelae. Therefore, some people call it ” Long COVID ” (Long COVID) .

However, a recent study published in JAMA published sub JAMA Internal Medicine massive investigation pointed out that so-called long-term COVID-19 symptoms may be more psychological rather than a viral infection caused by a COVID-19 , this conclusion in the public and scientists There has been a huge controversy between them.

The paper tile：Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic.

The research team from the University of Paris focused on 26,823 participants from all over France who participated in antibody testing to screen for COVID-19 infection.

The long-term COVID-19 is more of a psychological effect?

After the subjects received the results of the antibody test, the researchers asked if they believed they were infected with the new coronavirus and reported the long-term symptoms of the new coronavirus that have been widely reported before, such as fatigue, breathing difficulties or impaired attention.

The vast majority of participants (more than 25,000 people) tested negative for the COVID-19 antibody, indicating that they were not infected with the COVID-19 virus and they also believed that they were sick.

Of the approximately 1,000 people who tested positive, approximately 450 believed that they had contracted the new coronavirus.

About 460 people who tested negative for antibodies said they believed they were infected with the new coronavirus.

The research team found that people who believe they are infected with the COVID-19 virus, whether they are actually infected with the COVID-19 virus or not, are more likely to report that they have long-term symptoms of the COVID-19 virus.

At the same time, the research team also found that a positive COVID-19 antibody test is only consistent with one long-term symptom: loss of smell .

Based on the above findings, the research team concluded that the so-called long-term sequelae of the COVID-19 may be more related to the belief that you are infected with the COVID-19. It is a psychological effect, rather than caused by infection with the COVID-19 virus.

The study leader Cedric Lemogne professor table shows, study the reasons for these long-term COVID-19 symptoms is very important, and this study suggests that patients in our long-term COVID-19 may need to appear in the report again medical evaluation in order to prevent the symptoms of some of the reports Wrongly attributed to the COVID-19.

Voice of opposition

After the study was published, it was immediately met with strong dissatisfaction from many patients with COVID-19s, especially those with long-term symptoms of COVID-19s. They thought the conclusions of this study were like slandering them. The patient support organization ApresJ20 claimed that this study may lead to the stigmatization of long-term COVID-19 patients.

In addition, some researchers have questioned the method of this research. Some experts pointed out that antibody testing cannot always reliably detect previous COVID-19 infections. For long-term patients with COVID-19 who still feel unwell months after infection, antibody testing may be unreliable. British virologist Jeremy Rossman said that some studies on hospitalized patients with COVID-19 show that long-term COVID-19 patients tend to have weaker antibody responses.

The long-term COVID-19 itself has not been well defined, which also makes it difficult for related research to well define it. Current long-term COVID-19 research often involves more than a dozen symptoms, including loss of smell, joint pain, muscle aches, fatigue, inattention, skin problems, hearing impairment, constipation, dizziness, and so on. These vague symptoms can lead to vague diagnosis. If there is no clearer standard, some patients with COVID-19s may be mistakenly labeled as “long-term COVID-19s”.

Reference:
https://www.nature.com/articles/d41586-020-03360-8
https://www.nature.com/articles/s41591-021-01433-3
https://doi.org/10.1016/S0140-6736(21)01755-4
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785832

The long-term sequelae of COVID-19 is actually a psychological effect?

(source:internet, reference only)

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