October 5, 2022

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First epidemiological study: Omicron with significant immune escape

First epidemiological study: Omicron with significant immune escape



 

First epidemiological study: Omicron with significant immune escape.

[Heavyweight] The first epidemiological study of Omicron causing superinfection, showing that the phenomenon of immune escape is more significant.

 


On December 2, 2021, Pulliam of Stellenbosch University in South Africa and others uploaded the first research paper on Omicron mutant strains on bioRxiv, the title is “Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa” (The increased risk of SARS-CoV-2 superinfection in South Africa is related to the Omicron mutant ).

 

This blockbuster study describes the epidemiology of Omicron’s repeated infections .

 

In a cohort of 2,796,982 patients previously infected with SARS-CoV-2, the study found 35,670 repeat infections before November 27.

 

First epidemiological study: Omicron with significant immune escape

 


Studies have found that, compared with wild-type strains, Beta and Delta mutant strains increase the risk of initial infection (first infection) in the population , but do not increase the risk of reinfection, that is to say, the immunity formed after initial infection is against reinfection. Still valid. Omicron is contrary to the prevalence of the above two mutant strains.

 

The study found that Omicron did not increase the risk of initial infection in the population, and even the risk of initial infection in the population was reduced; but it increased the risk of reinfection .

 


First epidemiological study: Omicron with significant immune escape

 

In the second and third peaks dominated by Beta and Delta mutant strains, the hazard ratios of repeated infections were 0.75 and 0.71, respectively. In South Africa’s recent fourth peak led by Omicron, the hazard ratio of repeated infections rose to 2.39 .

 

First epidemiological study: Omicron with significant immune escape

 

 

 


In other words, the immune escape phenomenon of Omicron may be more significant .

Therefore, it is critical to continue to monitor its epidemic and conduct serological research.

 

 

 

 

 


references:
https://www.medrxiv.org/content/10.1101/2021.11.11.21266068v2.full.pdf

First epidemiological study: Omicron with significant immune escape

(source:internet, reference only)


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