Computer-simulated drug trial: Combining certain drugs with Ibuprofen can permanently damage kidneys
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Computer-simulated drug trial: Combining certain drugs with Ibuprofen can permanently damage kidneys.
Anyone who is taking a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure (hypertension) should be cautious about taking the pain reliever Ibuprofen at the same time, according to new research.
Diuretics and RSA inhibitors are often prescribed together for people with high blood pressure and are available under a variety of drug brands. Pain, fever, and anti-inflammatory drugs like Ibuprofen are available over-the-counter in most pharmacies and stores, and popular brands include Advil and Motrin.
Ibuprofen is a type of non-steroidal anti-inflammatory drug (NSAID) drug used to treat pain, fever, and inflammation.
This includes dysmenorrhea, migraines and rheumatoid arthritis.
Researchers at the University of Waterloo used computer-simulated drug trials to simulate the interaction of the three drugs and their effects on the kidneys.
They found that, in people with certain medical characteristics, the combination led to acute kidney injury, which in some cases could be permanent.
“It’s not like everyone who happens to take this combination will have a problem,” said Anita Layton, professor of applied mathematics at the University of Waterloo and Canada 150 Chair of Mathematical Biology and Medicine. “But studies have shown that this is enough to cause physical problems and patients should proceed with caution.”
Computer-simulated drug trials can quickly produce results that take longer in human clinical trials. Layton and her team use mathematics and computer science to bring cutting-edge insights to medical practitioners on issues such as drug complications.
In this case, too, the study could directly suggest that many people who are taking high blood pressure medication may be taking Ibuprofen without much thought.
“Diuretics are a family of drugs that make the body hold less water,” Layton said. “Dehydration is a major factor in acute kidney injury, and the combination of RAS inhibitors and Ibuprofen can cause a triple whammy to the kidneys. If you happen to be taking these high Blood pressure medication and need pain medication, consider acetaminophen instead.”
Layton and co-authors Jessica Little, Caroline Wang, and Francisco-J-Lopez-Hernandez’s new research paper, “Identifying Risk Factors for Triple Whammy Acute Kidney Injury,” is published in in Mathematical Biological Sciences.
Computer-simulated drug trial: Combining certain drugs with Ibuprofen can permanently damage kidneys
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