Genetically Edited Pig Kidneys Function Well After Transplantation to Humans
- Paternal Microbiome Perturbations Impact Offspring Fitness
- New Report Casts Doubt on Maradona’s Cause of Death and Rocks Manslaughter Case
- Chinese academician unable to provide the exact source of liver transplants
- Early Biomarker for Multiple Sclerosis Development Identified Years in Advance
- Aspirin Found Ineffective in Improving Recurrence Risk or Survival Rate of Breast Cancer Patients
- Child Products from Aliexpess and Temu Contain Carcinogens 3026x Over Limit
Genetically Edited Pig Kidneys Function Well After Transplantation to Humans
- AstraZeneca Admits for the First Time that its COVID Vaccine Has Blood Clot Side Effects
- Was COVID virus leaked from the Chinese WIV lab?
- HIV Cure Research: New Study Links Viral DNA Levels to Spontaneous Control
- FDA has mandated a top-level black box warning for all marketed CAR-T therapies
- Can people with high blood pressure eat peanuts?
- What is the difference between dopamine and dobutamine?
- How long can the patient live after heart stent surgery?
Genetically Edited Pig Kidneys Function Well After Transplantation to Humans
Scientists have demonstrated that genetically edited pig kidneys, when transplanted into the human body, can continue functioning for at least a week with no signs of rejection.
This groundbreaking case study holds promise for reducing organ waiting lists and associated mortality rates.
Organ transplantation remains the sole option in cases of advanced diseases, but finding suitable donors remains a challenge.
A technique known as “xenotransplantation” aims to expand the pool of donors beyond human donors.
Pig organs, due to their similar size, are considered prime candidates. To mitigate the risk of rejection, these organs undergo genetic editing, eliminating certain pig genes while introducing some human genes.
Recent successes have been achieved. Last year, the first pig-to-human heart transplant was conducted on a living patient, who survived for two months before succumbing to heart failure.
Other research groups implanted pig kidneys and hearts into patients declared brain-dead. In a three-day experiment, these organs functioned normally without signs of rejection, with patients sustained by life-support systems, having volunteered their bodies for the experiment.
A recent study by scientists at the University of Alabama extended the experiment to a full week.
The patient, a man in his 50s with a history of chronic kidney disease, exhausted all other options and was declared brain-dead. He received a pig kidney modified with 10 genetic alterations – four of which were gene knockouts to prevent potential rejection responses and six human genes to prevent clotting.
Over the course of seven days, biomarkers indicated excellent kidney function.
The transplanted kidneys successfully excreted urine, improved creatinine clearance rates in the blood (a key measure of kidney function), and showed no signs of micro blood clot formation.
While much work remains before such procedures can be routinely performed clinically, this marks a crucial step towards potentially reducing waiting lists and premature deaths among candidates.
Dr. Roger Lord, Senior Lecturer in Medical Science at the Australian Catholic University, stated, “Historically, xenotransplantation has largely failed due to post-operative hyperacute rejection, a process even immune suppression couldn’t control. This case study provides vital preliminary evidence that these genetically modified kidneys can function normally after xenotransplantation, bringing hope to those awaiting kidney transplants.”
This research was published in the Journal of the American Medical Association Surgery.
Genetically Edited Pig Kidneys Function Well After Transplantation to Humans
(source:internet, reference only)
Disclaimer of medicaltrend.org
Important Note: The information provided is for informational purposes only and should not be considered as medical advice.
