June 13, 2024

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Staying Up Late Without Sleep Causes Immune System Breakdown!

Staying Up Late Without Sleep Causes Immune System Breakdown!


Staying Up Late Without Sleep Causes Immune System Breakdown! Inadequate Sleep Damages Immunity, Even Recovery Is Hard to Reverse.

Sleep is a vital restorative process for the human body, rejuvenating the mind and relieving fatigue. Approximately one-third of a person’s life is spent in slumber, and quality sleep is recognized internationally as one of three key health benchmarks. Shortened or poor sleep, on the other hand, can negatively impact one’s well-being.

In today’s society, burning the midnight oil has become the new norm for many young people. Prolonged sleep deprivation poses significant health risks, as it is well-established to increase the risk of cardiovascular diseases, depression, diabetes, hypertension, and overall mortality.

Recently, researchers from the Icahn School of Medicine at Mount Sinai in the United States published a study titled “Sleep exerts lasting effects on hematopoietic stem cell function and diversity” in the Journal of Experimental Medicine.

This study revealed that adequate sleep plays a crucial role in regulating the body’s immune system, while sleep deprivation interferes with the formation and development of the innate immune system, increasing the risk of inflammation and heart disease. Even after sleep recovery, the inflammatory state in mice did not fully reverse.


Staying Up Late Without Sleep Causes Immune System Breakdown!



In the study, researchers examined 14 healthy adults who usually slept eight hours a night. The participants were divided into two groups, one sleeping 7.5 hours per night for six weeks and the other sleeping only six hours. After a six-week adjustment period, all participants returned to their regular eight-hour sleep schedule. After this adjustment period, the two groups swapped their sleep times. Blood samples were collected in the fifth and sixth weeks from participants in the morning and afternoon.

The study found that when participants lacked adequate sleep, they had higher levels of circulating monocytes in the afternoon, a greater number of immune stem cells in their blood, and evidence of immune activation.

Researchers noted that blood samples from sleep-deprived participants exhibited changes in DNA structure and an increase in immune cell numbers. Typically, an increase in the number of immune cells occurs during heightened states of inflammation. These changes, while not permanent, persist for several weeks at an accelerated rate of self-replication.


Staying Up Late Without Sleep Causes Immune System Breakdown!

Sleep deprivation promotes monocytosis in humans




Importantly, this heightened rate of immune cell replication can accelerate the development of age-related diseases, which in turn increases the risk of cardiovascular diseases.

Furthermore, researchers analyzed the impact of sleep deprivation on the immune system in mice. In a mouse model, one group was allowed to sleep without interruption while the other was woken up at night for 16 weeks, followed by 10 weeks of uninterrupted sleep recovery.

The analysis of immune stem cells in the mice that were awakened at night yielded results consistent with the human study.


Staying Up Late Without Sleep Causes Immune System Breakdown!Sleep recovery is not completely reversed


Researchers concluded that both in human and mouse models, sleep deprivation leads to increased inflammation in the bloodstream. Even after sleep recovery, mice that were awakened at night continued to display an aggravated inflammatory state, with some cells persisting that made the mice more prone to inflammation. The study in humans did not assess the recovery aspect.

The research underscores the importance of adults getting 7-8 hours of continuous sleep each night to help prevent inflammation and diseases, particularly for individuals with underlying health conditions.

Original Research Paper




Staying Up Late Without Sleep Causes Immune System Breakdown!

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