Breaking Cancer and Alzheimer’s is the future far away?

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Breaking Cancer and Alzheimer’s is the future far away?

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Breaking Cancer and Alzheimer’s is the future far away? Many globally renowned medical experts have shared their insights.

Experts from prestigious medical institutions such as Harvard Medical School, Stanford Cardiovascular Research Institute, MD Anderson Cancer Center, and the Department of Neurology at the University of California, San Francisco, with rich experience in treating and researching major diseases like Alzheimer’s and breast cancer, delved into innovative therapeutic approaches, cellular and gene therapies, and the clinical application prospects of these new treatment modalities.

Conquering Cancer, Cardiovascular Diseases, and Neurological Disorders

Cancer, cardiovascular diseases, and neurological disorders are three major challenges affecting global health, demanding revolutionary breakthroughs to better meet treatment needs. While breakthroughs like EGFR inhibitors and RAS inhibitors in targeted cancer therapy have saved countless lives, challenges such as overcoming resistance to targeted therapies and identifying more tumor-driving genes persist. With the development of novel treatment modalities like cell therapy and advances in disease detection technologies like proteomics and genomics, the question remains: how far are we from truly “curing” cancer?

In the realm of cardiovascular diseases, the landscape has transformed from a time when options were limited to now having various choices such as stent implantation, bypass surgery, implantable devices, and RNA therapy. Will personalized treatment for cardiovascular diseases experience a “qualitative leap” with the progress of emerging therapies and strategies involving new biomarkers? As gene editing enters the field of cardiovascular diseases, is the era of “curing” heart diseases approaching? Insights from Joseph Wu, President of the American Heart Association (AHA) and Director of the Stanford Cardiovascular Research Institute, will shed light on these questions.

Neurodegenerative diseases like dementia and Parkinson’s have long been challenging in clinical treatment. While a cure remains elusive, breakthroughs from amyloid-targeted therapies to CRISPR gene therapy offer hope. How significant are the breakthroughs in gene therapy for neurodegenerative diseases? The nascent stage of biologics in the field of neurological disorders is poised to change treatment landscapes. Professor Stephen Hauser, Department of Neurology at the University of California, San Francisco, will provide unique insights, drawing from his extensive work in the field of neurological diseases.

Addressing these major obstacles to meet treatment needs globally, let’s listen to the unique perspectives of renowned medical experts.

Three Breakthroughs Lead the Way to a New Era in Breast Cancer Treatment! Immunotherapy to “Unlock” More Effective Therapies

Breast cancer, with its high incidence and tumor-related mortality worldwide, has witnessed exciting developments in recent years. Immunotherapy, antibody-drug conjugates (ADCs), and targeted drugs such as CDK4/6 inhibitors for ER-positive breast cancer have brought new hope to patients. What are the potential of combined treatment strategies for breast cancer? What aspects of personalized treatment should be considered for different molecular subtypes of breast cancer? Strategies for managing metastases in breast cancer and the impact of the tumor microenvironment on treatment outcomes are crucial topics.

Sara Tolaney, Director of the Dana-Farber Cancer Institute Breast Tumor Center and Professor of Medicine at Harvard Medical School, a globally recognized leader in breast cancer research, will provide exclusive insights, playing a pivotal role in bridging the gap between the medical and industrial sectors in the development of targeted drugs, ADCs, and immunotherapy.

Milestone Breakthrough in Alzheimer’s Disease Treatment! What Breakthroughs Await in the Next 10 Years?

Alzheimer’s disease has severely impacted the health of millions globally, and finding effective therapies has been a formidable task. In July of this year, a landmark approval from the U.S. FDA was granted for lecanemab, a therapy targeting β-amyloid protein (Aβ). This approval comes 40 years after the first characterization of Aβ plaques. Professor Rudolph Tanzi, a key discoverer of amyloid-related genes and Professor of Neurology at Harvard University, describes the role of Aβ in Alzheimer’s disease as equivalent to lipids in coronary heart disease. What insights does genetic research provide for Alzheimer’s disease treatment strategies? Looking ahead to the next 10-20 years, what breakthroughs can we expect in Alzheimer’s disease treatment and prevention strategies?

Professor Rudolph Tanzi, a distinguished scholar in the field of CNS, recognized by Time magazine as one of the 100 most influential people in the world in 2015, has made pioneering contributions to the discovery of pathogenic genes for various CNS diseases, especially Alzheimer’s disease.

Will Cellular and Gene Therapies Rewrite Cancer Treatment?

Gene therapies are pioneering new frontiers in treatment. Two authoritative scholars explore the vast prospects of gene therapies transforming the clinical treatment paradigm and the technological innovations accelerating this breakthrough, such as organoid models and molecular diagnostics. What innovations, from organoids to molecular diagnostics, will catalyze clinical breakthroughs? Looking ahead, will cellular and gene therapies rewrite cancer treatment, even shining in the pre-cancer prevention stage?

Professor Catriona Jamieson, Professor of Medicine and holder of the Sanford Stem Cell Clinical Center Endowed Chair at the University of California, San Diego School of Medicine, a specialist in hematologic malignancies, along with Professor David Schaffer from the University of California, Berkeley, delve into these questions. Professor Schaffer, a leading figure in developing next-generation gene therapies, focuses on designing targeted and efficient viral vectors for gene therapy and developing new technologies for regulating stem cells. The technologies he has been involved in are already applied in eight clinical trials.

Breaking Cancer and Alzheimer’s is the future far away?

References:

[1]Advances in Stroke: Brain Health in 2023. Stroke. doi: 10.1161/STROKEAHA.123.043019
[2]A first-in-human phase I study of a novel KRAS G12D inhibitor HRS-4642 in patients with advanced solid tumors harboring KRAS G12D mutation

(source:internet, reference only)

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