Study finds blood type linked to increased stroke risk in adults under 60
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Study finds blood type linked to increased stroke risk in adults under 60.
The researchers examined nearly 50 previously published studies on the relationship between genes and ischemic stroke and found that blood type may play a role in the likelihood that young adults experience this life-threatening event.
“The number of people with early strokes is on the rise. These people are more likely to die from life-threatening events, and survivors can face decades of disability,” explains Steven Kittner of the University of Maryland Medical Center, co-leader of the new study. … Despite this, there has been very little research into the causes of early stroke.”
Building on several years of research into the relationship between blood type and clotting, Kittner and colleagues conducted a meta-analysis that pooled data from 48 different studies.
The focus was on genetic differences between approximately 17,000 stroke patients and 600,000 healthy controls, all between the ages of 18 and 59.
The research focused on a specific gene variant that appears to be associated with a higher risk of early-onset stroke. This gene determines a person’s blood type.
Compared with people with other blood types, people with type A blood were 16 percent more likely to have a stroke before the age of 60, the findings showed.
People with blood type O were the least likely to experience an early stroke, about 12 percent less likely than people with all other blood types.
After age 60, no differences in stroke risk were found between different blood groups.
“This study raises an important question that requires a more in-depth investigation of how our genetically determined blood type plays a role in early stroke risk,” said Mark Gladwin of the University of Maryland School of Medicine.
So, what could be going on here? The researchers said there was previous evidence of clotting differences between blood types.
Those with blood type A were found to be at greater risk of suffering from clotting conditions, such as deep vein thrombosis, while those with blood type O tended to be more likely to experience serious bleeding events.
“We still don’t know why blood type A carries a higher risk, but it’s likely related to clotting factors like platelets and cells lining blood vessels, as well as other circulating proteins, all of which play a role in the development of blood clots, ” Kittner noted. “We clearly need more follow-up studies to clarify the mechanisms of increased stroke risk.”
The new study was published in the journal Neurology .
Reference:
https://n.neurology.org/content/early/2022/08/31/WNL.0000000000201006
Study finds blood type linked to increased stroke risk in adults under 60
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