Why is high consumption of fish linked to increased risk of melanoma?
- Subversive discovery: Can lymph nodes promote the success of cancer immunotherapy?
- Major Discovery: Cancer cell PD-L1 does not inhibit T cell toxicity
- The new coronavirus may kill cancer cells and achieve a permanent cure!
- Why did the Alzheimer’s drug candidate BACE1 inhibitor fail?
- LRTI Death: Research spanning 80 years confirms for the first time
- The decline of the global antibiotic market is threatening the development of new drugs
Why is high consumption of fish linked to increased risk of melanoma?
- More than 1 million Chinese died after China quit “Zero-COVID policy”?
- Why is Vinyl chloride listed as a Class A “known human carcinogen” ?
- First human trial of HIV gene therapy: A one-time cure will be achieved if successful!
- New breakthrough in CAR-T cell therapy: Lupus erythematosus patients achieved treatment-free remission for up to 17 months
- How long can the patient live after heart stent surgery?
- First time: Systemic multi-organ recovery after death
Why is high consumption of fish linked to increased risk of melanoma?
High consumption of fish — including tuna and non-fried fish — appears to be associated with an increased risk of malignant melanoma, according to a large study of U.S. adults published in the journal Cancer Causes and Control .
“Melanoma is the fifth most common cancer in the U.S., with a lifetime risk of 1 in 38 for whites, 1 in 1,000 for blacks, and 1 in 167 for Hispanics,” said corresponding author Eunyoung Cho. Fish intake in the United States and Europe has increased in recent decades, but previous studies investigating the association between fish intake and melanoma risk have been inconsistent. Our findings identify a need for further investigation connection.”
According to researchers at Brown University, people with an average daily fish intake of 42.8 grams had a 22 percent higher incidence of malignant melanoma compared to those with an average daily fish intake of 3.2 grams.
In addition, they found that people who ate 42.8 grams of fish per day had a 28 percent chance of developing abnormal cells in only the outer layer of the skin, commonly referred to as stage 0 melanoma or melanoma in situ, compared to those who ate 3.2 grams per day. An average serving of cooked fish weighs about 140 grams.
The scientists analyzed data from 491,367 NIH-AARP Diet and Health researchers recruited from across the United States between 1995 and 1996 to investigate the relationship between fish consumption and melanoma risk.
Participants with an average age of 62 answered questions about their consumption patterns and portions of fried, non-fried and tuna over the past year.
Using information from cancer registries, the researchers determined the incidence of new melanomas that emerged over a median period of 15 years.
They also took into account an individual’s body mass index, level of physical activity, smoking history, daily calorie and caffeine consumption, family history of cancer, and the average amount of UV radiation in their vicinity.
During the study period, 5034 participants (1.0%) developed malignant melanoma and 3284 (0.7%) developed stage 0 melanoma.
The researchers found that higher intakes of non-fried fish and tuna were associated with an increased risk of malignant melanoma and stage 0 melanoma.
Those with a median daily intake of 14.2 grams of tuna had a 20% higher risk of malignant melanoma and a 17% higher risk of stage 0 melanoma, while those with a median daily intake of 0.3 grams of tuna people.
Median intake of non-fried fish of 17.8 g per day was associated with an 18% higher risk of malignant melanoma and a 25% higher risk of stage 0 melanoma compared with a median intake of 0.3 g per day of non-fried fish.
The researchers found no significant association between eating fried fish and the risk of malignant melanoma or stage 0 melanoma.
Eunyoung Cho said: “We speculate that our findings may be due to pollutants in fish, such as PCBs, dioxins, arsenic and mercury. Previous studies have found that higher fish intake is associated with were associated with higher levels of these pollutants in the body and found an association between these pollutants and a higher risk of skin cancer. However, we note that our study did not investigate the concentrations of these pollutants in Further research is needed to confirm this relationship.”
The researchers caution that the observational nature of their study does not allow conclusions to be drawn on a causal relationship between fish intake and melanoma risk.
They also didn’t take into account some risk factors for melanoma in their analysis, such as the number of moles, hair color, history of severe sunburn and sun-related behaviors.
Also, because the average daily fish intake was calculated at the start of the study, it may not be representative of the participants’ lifetime diet.
The authors suggest that future research is needed to investigate fish components that may contribute to the observed association between fish intake and melanoma risk, as well as any biological mechanisms behind this.
Currently, they do not recommend any changes to fish consumption.
Why is high consumption of fish linked to increased risk of melanoma?
(source:internet, reference only)
Disclaimer of medicaltrend.org
