May 26, 2024

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Dutch Man Infected with COVID-19 for 613 Days Dies: Accumulating Over 50 Virus Mutations

Dutch Man Infected with COVID-19 for 613 Days Dies: Accumulating Over 50 Virus Mutations



Dutch Man Infected with COVID-19 for 613 Days Dies: Accumulating Over 50 Virus Mutations

A 72-year-old man in the Netherlands has set a new record for the longest duration of COVID-19 infection, enduring the illness for 613 days and accumulating over 50 mutations of the virus in his body. Researchers from the University of Amsterdam recently stated that this is the longest individual case of infection recorded to date.

Previously, the longest recorded individual case of COVID-19 infection was a man from the UK who was infected for 505 days before his death.

 

 

Dutch Man Infected with COVID-19 for 613 Days Dies: Accumulating Over 50 Virus Mutations

 

Medical center personnel from the university will present this case at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024) later this month.

The patient was diagnosed with the Omicron variant infection in February 2022. Due to his previous battle with blood cancer, despite receiving multiple vaccinations, his immune system was unable to produce enough white blood cells or antibodies to combat the virus effectively.

Despite various treatment attempts, his body developed resistance to the medications, and his immune system was unable to clear the virus efficiently. Due to a weakened immune system and a relapse of his blood cancer, the patient passed away in the autumn of 2023 in the hospital.

Through multiple sampling and analysis, the research team at the University of Amsterdam found that the COVID-19 virus underwent nearly 50 mutations during its latency in the man’s body, some of which allowed the virus to evade his immune system’s defenses, ultimately forming a “super mutant variant.”

However, there is currently no evidence to suggest that he transmitted this “super mutant variant” to others.

“Infection with COVID-19 for 20 months” and “super mutations” may sound alarming, but medical student Magda Vogt from the University of Amsterdam Medical Center stated, “In this case, the duration of infection is extreme. Long-term infection in immunocompromised patients is more common than in the general population.”

The European Congress of Clinical Microbiology and Infectious Diseases also pointed out that healthy individuals infected with the COVID-19 virus typically clear the virus within days to weeks, but those with weakened immune systems may continue to be infected, prolonging the replication and evolution of the virus. Some believe that the initial emergence of the Omicron variant may have originated from immunocompromised patients, highlighting the importance of close genomic monitoring of such patients.

Previous studies have also found that “long COVID” (symptoms persisting for at least 2 months after COVID-19 infection, with symptoms persisting for 3 months) is more common and severe among those infected with COVID-19 before the 2021 variants, unvaccinated individuals, or those who have been infected multiple times.

Dutch Man Infected with COVID-19 for 613 Days Dies: Accumulating Over 50 Virus Mutations

(source:internet, reference only)


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