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A UK man infected with COVID-19 for 300 days and the virus has mutated
A UK man infected with COVID-19 for 300 days and the virus has mutated. People with weakened immune systems may be infected with the new coronavirus for a long time, some for more than 6 months.
According to Fox News, the United Kingdom has reported a long-term case of new coronavirus infection. This 72-year-old man has been infected for nearly 300 days, which is the longest known case of infection.
According to Andrew Davidson, a virologist at the University of Bristol, there have been more and more reports showing that people with low immune function may be infected with the new coronavirus for a long time, some for more than 6 months. Viruses can mutate and evolve during infection, so we should try to eliminate the virus in every possible way while monitoring the changes in the virus.
The report pointed out that the 72-year-old British man had a low immune system, had suffered from cancer, and was a high-risk group of long-term infections. Six months after he was infected, he still tested positive for the new coronavirus. On 213 days after the infection, the researchers used a 15-day course of remdesivir treatment, but the virus was not successfully cleared; on the 265th day, the patient received two monoclonals Antibody casirivimab and imdevimab therapy, this therapy has not yet been clinically approved in the UK, belongs to “sympathetic use”. Since then, the patient’s health status has been significantly improved, and no virus can be detected in the body after 45 days.
The researchers sequenced the virus genome and found that the virus spike protein has two deletions (δH69/δV70), and the current B.1.1.7 mutant virus also has this kind of deletion. At the same time, the researchers discovered this virus mutation in another patient with immunodeficiency COVID-19 pneumonia who had received convalescent plasma antibody therapy. It can be seen that this type of spike protein deletion mutation may be more common in immunodeficiency patients.
Davidson pointed out that the case proved that people with immunodeficiency or immunocompromised are prone to long-term chronic infection of the new coronavirus. This infection may not lead to emergency hospitalization, but it will bring symptoms of fatigue, discomfort and dyspnea. Such long-term cases are also prone to virus mutations, making it more difficult to prevent and control the epidemic. On the other hand, this case proves the effectiveness of monoclonal antibody therapy. For patients with weakened immune function and long-term persistent infection, there are currently therapies that can clear the virus. We need further experiments to eliminate the virus in this part of the population.
Researchers will also study the relationship between the weakened immune response in the body and virus mutations, and will also conduct further studies on other long-term persistent infection cases, analyze their virus mutations in their bodies, and develop better treatment options.
(source:internet, reference only)