The era of immune cell therapy has arrived!

The era of immune cell therapy has arrived! More and more patients will benefit from it. More and more adults around the world choose to store immune cells when they are young and healthy for future needs.

2021 has come. Looking back at 2020, breakthroughs have been made in basic research and clinical trials on immune cells at home and abroad, and a series of remarkable achievements have been obtained. Immune cell therapy has also become the most cutting-edge, hottest and most concerned treatment in the field of cancer treatment.

Up to now, more than 50 CAR-T cell clinical IND applications from 28 domestic companies have been accepted (including multiple clinical trial applications for the same product), and a total of 31 clinical approvals have been obtained, 12 of which were approved in 2020 of. Immune cell therapy is getting closer and closer to us.

This article will summarize the research and treatment cases of immune cells in 2020, so that everyone can better understand the potential of immune cells to protect the human body and treat diseases.

Research on immune cells in COVID-19 pneumonia

The outbreak of the novel coronavirus (COVID-19) at the beginning of 2020 has made people realize that in the absence of specific medicines, a healthy immune system is vital to people’s survival, and there is also an issue about the role of immune cells in COVID-19. Several studies have been conducted.

In January 2020, the US Sorrento Pharmaceuticals and Celularity Cell Therapy jointly announced an attempt to use placenta-derived natural killer (NK) cell drug CYNK-001 to treat and prevent coronavirus. Subsequently, the US FDA approved a new drug clinical trial application for this therapy for the treatment of adult patients with COVID-19 pneumonia.

In February 2020, the academician Wang Fusheng’s team released the world’s first new type of coronavirus pneumonia pathological anatomy report on The Lancet, revealing that the number of T lymphocytes in the patient’s peripheral blood has been greatly reduced, which may be related to the severity of the disease and mortality. Related key factors.

In December 2020, Dan Barouch, director of the BIDMC Virology and Vaccine Research Center, and his colleagues published a new paper in the journal Nature, clarifying that antibodies and immune cells in rhesus monkeys protect SARS-CoV-2 (causing COVID-19 virus).

Research on the protection of human body by immune cells

Immune cells are the police to defend humans, responsible for cleaning up body waste and resisting foreign pathogens. About how immune cells function, 2020. Scientists have also appeared a lot about this research.

(1) The tricks used by immune cells to deal with germs

As the guardian of the human body, immune cells will do their best to resist foreign germs and use various skills to eliminate foreign invaders. For example, killer T cells use “super bombs” to bomb target cells to kill dangerous aliens. In order to reach the infected tissue as soon as possible, neutrophils will migrate through narrow tissue gaps under the guidance of chemical signals from damaged tissues and bacteria.

(2) Immune cells in abdominal fat can be used to reverse chronic low-grade inflammation and aging processes.

In July 2020, Dr. Mario Notti, a scientist from the Institute of Biomedical Research, Institute of Pathology, and University Hospital of Berne, proved that the immune cells in abdominal fat can be used to reverse chronic low-grade inflammation and aging.

Some clinical cases of immune cell therapy in 2020

Immune cells can protect the body from pathogens. At the same time, with the help of technology, they are also used to treat clinical diseases. In 2020, immune cells will also successfully help some patients regain their health and free them from the torture of diseases.

1. She was suffering from tumor and lupus erythematosus, CAR-T cell immunotherapy allowed her to be cured successfully

Ms. Wang in China unfortunately suffers from systemic lupus erythematosus and diffuse large B-cell lymphoma. The tumor is located in the right knee joint and is more than ten centimeters in diameter. It has invaded the femur, left inguinal lymph nodes and bone marrow. When she was desperate, Ms. Wang joined the group to participate in the clinical trial of CAR-T cell immunotherapy in Peking University Shenzhen Hospital, and received the treatment of compound dual-target CAR-T cell immunotherapy. 9 months after treatment (2020 June) After re-examination, in addition to the complete removal of the original lymphoma, the refractory lupus erythematosus antibodies in her body for many years also turned negative, which means that her lupus erythematosus has been clinically cured.

2. From lymphoma to cancer cells disappeared, CAR-T immunotherapy saves a happy family

In 2018, a woman from the United Kingdom, Helensius, unfortunately got lymphoma, and conventional cancer treatments did not help. Last fall, her cancer had spread to the bone marrow, liver and lungs. The doctor told her to prepare for the worst. In 2019, Helen found that conventional treatments were not effective. Fortunately, at the beginning of this year, Ms. Hughes was notified that she could receive a new type of T cell immunotherapy, which was just approved by the British National Health System NHS. Six months after receiving the CAR-T cell infusion, the doctor recently performed an examination for her and told her that the cancer cells had completely disappeared from her body.

3. Cancer cells dropped from 68 to 2. Immune cell therapy gave the singer hope

A 31-year-old singer in Hong Kong has been actively fighting cancer since he was diagnosed with nasopharyngeal adenoid cystic carcinoma. After 9 years, the condition has been repeated repeatedly without a radical cure. With the help of many friends and celebrity friends, recently successfully raised donations for “immune cell” therapy. The singer successfully completed the first course of treatment early last month. On November 21, 2020, the singer posted a very exciting event on her personal social account. She said: “After a month of recuperation! The blood circulating tumor cells (CTC) were tested, and the doctor said that it is active in my body. Cancer cells have dropped from 68 to 2 in the first time!”

Summary

In recent years, tumor immune cell therapy has brought miracles to cancer treatment, adding milestones one after another to the history of human anti-cancer. Immune cell therapy has been written into some countries’s “Thirteenth Five-Year” Pharmaceutical Industry Development Planning Guide. , Cell therapy products such as CAR-T are listed as the key areas to promote the development. For the coming 2021, I believe that there will be more breakthroughs in immune cell therapy, and immune cell therapy will bring more and more hopes to patients. At the same time, the concept of storing healthy immune cells at a young age has become more and more popular. More and more adults around the world choose to store immune cells when they are young and healthy for future needs.

(source:chinanet, reference only)

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