Stem cell therapy technology to treat uremia

Stem cell therapy technology to treat uremia. Stem cell therapy is expected to help uremic patients embark on the road to recovery. Uremia is not an independent disease, but a clinical syndrome shared by various advanced kidney diseases. It is a syndrome composed of a series of clinical manifestations that appear when chronic renal failure enters the terminal stage.

Uremia is a chronic process that develops continuously. Chronic nephritis, renal failure, and uremia are the dangerous trilogy of the development of nephropathy. This process may be very hidden and undetected, so that it is too late to discover. When it develops to this stage of uremia, the number of damaged kidney cells increases, and renal fibrosis damage has already accounted for the majority, which can cause symptoms of various systems throughout the body.

Uremia

The kidney has a strong compensatory function, including excretion of metabolic waste in the body, maintaining body fluid, electrolyte and acid-base balance, as well as endocrine function, by secreting certain hormones, regulating blood pressure, regulating calcium and phosphorus metabolism, and promoting bone marrow to produce red blood cells.

When kidney function is impaired due to various reasons, and the end-stage renal failure progresses, the metabolites, toxins, and water in the body will not be excreted in time, which will cause the body’s internal biochemical processes to be disordered, and the endocrine function of the kidneys is also damaged , Causing a series of syndromes, this is uremia.

The early symptoms of uremia mainly include yellowing complexion, fatigue, headache; poor appetite, anorexia, nausea; body swelling; decreased urine output, less frequent visits to the toilet, etc. There are many reasons for uremia, such as accelerated life rhythm, heavy work pressure, less rest and sleep, and excessive fatigue; too much entertainment, intemperate diet, high-protein, high-fat, and high-purine foods, all invisibly increase the burden on the kidneys.

Currently, renal replacement therapy includes hemodialysis, peritoneal dialysis and kidney transplantation. However, dialysis will gradually shrink the kidneys. After kidney transplantation, infection and various complications must be prevented, and it is inevitable to take immune drugs for life.

Stem cell treatment of uremia

Stem cells use their strong proliferation ability and multidirectional differentiation potential to produce a large number of offspring or various types of cells needed to differentiate into the human body, and exert their self-replication and differentiation potential to repair damaged cells and restore the functions of damaged organs and tissues. It can repair glomerular endothelial cells and mesangial cells. Mesenchymal stem cells can repair pancreatic function, strengthen insulin metabolism, regulate blood sugar, reduce damage to the kidney, and help restore various cellular functions of the kidney tissue.

After the stem cells enter the renal blood vessels, the kidney lesion will send out a certain signal to attract, prompting the stem cells to produce a large number of progeny cells, and these progeny cells will continue to differentiate into various types of cells needed by the kidney.

Improve the local microcirculation of the kidney, reduce the high pressure in the glomerulus, relieve the renal ischemia and hypoxia state, so that the blood circulation of the whole body can be continuously restored and improved, and certain active factors released can also stimulate the secretion of erythropoietin in the kidney cells. The erythropoietin can promote the production of red blood cells, thus alleviating the body’s anemia.

It also suppresses the immune response, differentiates into immune cells, regulates the function of the immune system to return to normal, and achieves the goal of gradually repairing the kidney.

Due to the critical condition of uremia, early treatment of nephropathy is necessary to control and delay the progression of the disease, reduce the incidence of uremia, and pay attention to diet and rest. It is believed that in the near future, stem cell therapy technology can help more uremia patients and allow more patients on the road to recovery.

(source:chinanet, reference only)

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