June 30, 2022

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Can atrophic gastritis become cancer?

Can atrophic gastritis become cancer?

 

Can atrophic gastritis become cancer? Chronic atrophic gastritis is a disease in which the epithelium of the gastric mucosa is repeatedly damaged, causing the proper mucosal glands to shrink and disappear. It is a chronic gastritis.

Can atrophic gastritis become cancer?


Chronic atrophic gastritis is a disease in which the epithelium of the gastric mucosa is repeatedly damaged, causing the proper mucosal glands to atrophy and disappear. It is a chronic gastritis, often accompanied by intestinal metaplasia, referred to as intestinal metaplasia. The patient may have fullness, discomfort or pain in the upper abdomen, which is more obvious after a meal, and may be accompanied by other dyspeptic symptoms such as belching, acid reflux, nausea, vomiting, loss of appetite, etc. Gastroscopy and pathological examination can confirm the diagnosis, and pathological results are the gold standard for diagnosis.

Atrophic gastritis or intestinal metaplasia is a precancerous disease. It is the background soil for precancerous lesions such as dysplasia or intestinal gastric adenoma. Patients with atrophic gastritis have a higher risk of gastric cancer than normal people, but chronic atrophic gastritis does not necessarily develop Into stomach cancer.

In fact, only a small percentage of patients with atrophic gastritis may develop into gastric cancer. The general experience from atrophic gastritis to gastric cancer is: atrophic gastritis-intestinal metaplasia-dysplasia-carcinoma in situ-invasion (invasive cancer) -Metastasis (advanced cancer) and a series of processes, in which dysplasia is divided into three stages, namely mild-moderate-severe dysplasia, which is by no means an overnight process.

Atrophy can be reversed in some patients. Intestinal metaplasia is usually difficult to reverse, but it may not progress to dysplasia. Even if mild or moderate dysplasia (now also called low-grade intraepithelial neoplasia) occurs, it is often reversible. Yes, if effective intervention and reasonable treatment are involved in this process, the condition of most patients can be controlled or even reversed, and there is no need to worry too much.

At this time, various pathogenic factors should be removed. If there is Helicobacter pylori infection, it must be eradicated. If the body’s folic acid level is low, it should be supplemented appropriately. It can also be treated with Chinese medicine such as Weifuchun. In life, eat more fresh For vegetables and fruits, pay attention to balanced nutrition, avoid smoking and drinking, avoid excessive intake of salt, avoid eating fast foods such as mildew, pickled, grilled and fried foods, and pay attention to dietary hygiene.

However, it should be noted that once it has developed to severe dysplasia or carcinoma in situ (also known as high-grade intraepithelial neoplasia), the possibility of reversal is very low. In order to avoid further development into invasive cancer (invasive cancer requires surgery Surgery, radiotherapy and chemotherapy), the lesion should be removed under gastroscopy in time.

For patients with chronic atrophic gastritis, the most important thing is to monitor the dynamic changes of the lesions, and to review the gastroscope regularly. If the lesions do have progress, they can be detected in time and treated as soon as possible. Reined in order to prevent cancer. How long is the review time? It is generally believed that moderate to severe chronic atrophic gastritis has a certain cancer rate.

In order to reduce the occurrence of gastric cancer, as well as to facilitate patients and meet the requirements of medical economics, biopsy of chronic atrophic gastritis with moderate to severe atrophy and intestinal metaplasia is followed up once a year, without intestinal metaplasia or intraepithelial neoplasia Chronic atrophic gastritis can be followed up with endoscopy and pathology as appropriate.

Accompanied by low-grade intraepithelial neoplasia and confirmed that this specimen is not from a person adjacent to the cancer, according to endoscopy and clinical conditions, the follow-up is shortened to about 6 months; while high-grade intraepithelial neoplasia needs to be confirmed immediately, and endoscopy is performed after confirmation Under treatment or surgery.

 

(source:internet, reference only)


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