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The cause of Alzheimer’s is finally revealed!
The cause of Alzheimer’s is finally revealed! It may be too late in these situations, and the two methods to test risks.
Elderly people with mild cognitive impairment, they are forgetful, amnesia, will serve the wrong food, will forget to collect money, will forget yesterday’s appointment, will have the illusion of time and space, they do not know where they are for a while , Sometimes there are “strange” emotions, and even some behaviors that are difficult for me to understand…The unprepared forgetting makes this old man full of serious anxiety.
Such elderly people are Alzheimer’s patients. Many patients have already deteriorated to moderate to severe disease at the time of diagnosis and missed the optimal treatment stage. So, let’s take a look at Alzheimer’s disease with everyone today.
1 What is depriving old people of memory?
At present, there are at least 35 million Alzheimer’s patients in the world, and China accounts for about a quarter, ranking first in the world. More research predicts that by 2050, China’s Alzheimer’s disease patients will exceed 40 million, which seems to be a public health problem that seriously affects the quality of life.
People, how come Alzheimer’s is good? What happened in their brains?
Studies have found that Alzheimer’s disease will have typical histopathological changes-amyloid plaque deposition and neurofibrillary tangles in the brain.
A potentially toxic protein in the human brain, β-amyloid, will form amyloid plaque deposits when it accumulates excessively, thereby poisoning cells, destroying nerve transmission, and increasing the risk of Alzheimer’s disease.
There is also a kind of Tau protein in the brain, a phosphate-based protein. The normal Tau protein molecule contains 2 to 3 phosphate groups, while the Tau protein in the brain of Alzheimer’s patients is abnormally hyperphosphorylated. Tau protein per molecule It can contain 5-9 phosphate groups, and will lose normal biological functions, form neurofibrillary tangles, kill brain cells, and gradually lose memory, thinking and reasoning ability.
2 Risk factors for Alzheimer’s disease
Alzheimer’s disease is the result of genetic, lifestyle, and environmental factors. However, the following five factors will invisibly increase the risk of disease:
Studies have shown that tau protein, which is closely related to Alzheimer’s disease, is more likely to spread in the aging brain. Moreover, Alzheimer’s disease is a progressively developing neurodegenerative disease. With the increase of age, the prevalence of Alzheimer’s disease also increases year by year. At present, the incidence rate of elderly people over 85 years old is as high as 20%.
2) Cardiovascular and cerebrovascular diseases
Cardiovascular and cerebrovascular diseases such as high blood pressure and high cholesterol can easily cause damage to blood vessels and functional decline, thereby affecting the vascular barrier function and the peripheral nervous system, leading to the weakened ability of patients to perceive changes in the internal and external environment, causing Alzheimer’s disease.
In addition, the cholesterol contained in the cell membrane of brain neurons is a catalyst for the accumulation of beta amyloid, which can make it accumulate 20 times faster, making it easier to form amyloid plaque deposits in the brain, which greatly increases the incidence of Alz in patients with high cholesterol. The risk of Haimer disease.
3) Bad lifestyle
Bad lifestyle habits such as smoking, lack of sleep, and lack of exercise can also increase the risk of Alzheimer’s disease.
◎Insufficient sleep will cause the Tau protein level in the blood to increase by 17%; and poor sleep quality is equivalent to the brain is still working, constantly producing garbage and harming brain health.
◎Long years of smoking can cause cerebral arteriosclerosis and insufficient blood supply, leading to neuronal disease, causing different degrees of atrophy of brain tissue, and increasing the risk of Alzheimer’s.
Obesity is one of the risk factors for Alzheimer’s and related diseases. Obese people are more prone to inflammation, oxidative stress, insulin resistance, etc., which can damage brain cells and increase the risk of dementia.
Studies have shown that compared with women aged 20 to 49 with normal weight, the risk of dementia in overweight people increases by 82%, and the risk of dementia in obese people increases by 145%; while men aged 20 to 49 are obese, the risk of dementia increases after 70 years of age 147 %; Obesity is only between 50 and 69 years old, and the risk of Alzheimer’s disease increases by 100%.
5) Educational level and social skills
The brain is like a muscle, which is used to advance and retreat. When we learn and touch new things, it can promote the establishment of new connections in the brain and effectively prevent brain degeneration. People with low education and lack of social interaction are more likely to age earlier and cause dementia.
3 Alzheimer’s disease has these four stages
According to the severity of the patient’s cognitive impairment, Alzheimer’s disease can be divided into four stages of development:
1) Pre-dementia stage
The ability to learn and preserve new knowledge is reduced, memory is slightly impaired, and occasionally forgetful, but it does not affect the basic ability of daily living, and has not reached the level of dementia.
2) Mild dementia stage
Patients with memory loss, often forget what they do, and even gradually forget the things and people in the past, and begin to find no way home; they are prone to anxiety and fatigue when facing unfamiliar and complicated things.
3) Moderate dementia stage
The patient’s social contact ability is reduced; there are speech repetitions, a decrease in calculation ability and obvious visual space obstacles, such as unable to find their own bedroom at home; symptoms such as aphasia, apraxia, and cognition gradually appear; obvious behaviors and mental disorders .
4) Stages of severe dementia
The above-mentioned symptoms are gradually aggravated; crying and laughing are impermanent, speech ability is lost, and simple dressing and eating cannot be completed; limb stiffness or flexion paralysis; lung and urinary tract infection, pressure sores, systemic failure symptoms, etc. Eventually may die due to complications.
Alzheimer’s disease has an insidious onset and is not easy to be detected. When the symptoms worsen, it is often in the middle and late stages. Therefore, if you are worried that you or your family are at risk of illness, you can take the following methods for regular testing.
①Thumb self-test method
Touch the thumb of the left hand with the index finger of your right hand, and quickly switch after touching it, instead touch the thumb of the right hand with your left index finger.
Perform this movement alternately with both hands uninterrupted, the faster the better. If the speed is very slow, or the two fingers always miss, you need to be alert that the brain function has been abnormal, and it is recommended to go to the hospital for further examination.
②AD-8 early screening
Note: AD-8 can be used for self-examination by the elderly with adequate cognitive function, or answered by an insider who knows the subject. Regular testing is required for the elderly. If there are 2 or more changes, you need to go to the hospital for further treatment.
4 Develop these habits daily
Help you stay away from Alzheimer’s
At present, Alzheimer’s disease is still a worldwide problem, but after investigating big data samples, scientists have discovered that certain interventions can reduce the risk of disease.
1) Keep a good sleep
In daily life, young people should maintain 7-9 hours of high-quality sleep, while for the elderly over 65, getting enough sleep for 6 hours a day is more beneficial to the body. The specific time varies from person to person. Good sleep should have the following characteristics:
① Fall asleep fast, you can fall asleep in about 10 minutes after going to bed.
②Deep sleep, even breathing, not easy to wake up.
③ Feel comfortable and energetic after getting up.
④ High working and living efficiency during the day and a clear mind.
2) Maintain a healthy weight
Obesity is not good, but underweight also has various harms, especially after 60 years old, it is healthier to be moderately overweight.
People who are underweight are likely to have malnutrition. At this time, immunity and physical resilience will decrease and the risk of disease is higher. In the fight against diseases, a good physical condition and nutritional status are more necessary.
People under the age of 60: The weight remains within the normal range (that is, the BMI is between 18.5 and 24.9), and the mortality rate is low.
People over 60 years old: People with BMI in the overweight category (ie, BMI between 25 and 29.9) have the lowest mortality rate.
3）Actively use your brain and maintain a good attitude
Studies have shown that long-term depression can easily cause cognitive decline and increase the risk of Alzheimer’s disease in later life. Therefore, we must maintain a good attitude and actively use our brains. Reading, playing chess or talking with people will help to exercise the brain. .
4 ）Supplement nutrients
Sufficient lecithin can ensure the synthesis of “choline” and “acetyl” in the body into “acetylcholine”, and acetylcholine can increase the degree of activation of brain cells and help improve memory ability. Daily supplements of lecithin can be achieved through intake of milk, meat, eggs, beans, nuts and other foods.
DHA, also known as “brain gold”, is an essential element for the growth and maintenance of nerve cells. The elderly can eat more fish and dried fruit to supplement DHA, which can improve the degraded brain nerve function and memory. Recovery, assist in preventing Alzheimer’s disease.
Neural acid is known as the “invisible yellow bracelet” for patients with Alzheimer’s disease. It is the core natural component of nerve fibers and nerve cells in the brain. It can induce the self-growth, division and repair of nerve fibers, and enhance the relationship between nerve tissues. Signal conduction, thereby delaying brain aging. However, it is difficult for the human body to produce nervonic acid, and it can be supplemented by in vitro intake under the guidance of a doctor.
(sourceinternet, reference only)