October 5, 2022

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Stem cells can effectively treat liver failure

Stem cells can effectively treat liver failure


Stem cells can effectively treat liver failure. The infection rate of hepatitis has been effectively controlled in many countries, but the treatment of hepatitis B is still difficult. Hepatitis B, which can be prevented and detected by a vaccine, still cannot be cured. Complete elimination of hepatitis B virus in the body has never been achieved. How to treat those who have been infected and carry the virus is still a big problem.

Stem cells can effectively treat liver failure


Hepatitis B trilogy-hepatitis, cirrhosis, liver cancer

I believe everyone knows all about these trilogy. In the hepatitis stage, it can also be used for antiviral treatment and control the development of the disease; in the liver cirrhosis stage, the necrotic liver tissue is difficult to regenerate; in the liver cancer stage, the word N is omitted here.

Terrible liver failure

Liver failure refers to severe liver damage caused by a variety of factors, leading to serious impairment or decompensation of its synthesis, detoxification, excretion, and biotransformation functions. The occurrence of coagulation mechanism disorders and jaundice, hepatic encephalopathy, ascites, etc. A group of clinical symptoms manifested, the clinical manifestations are extreme fatigue, and severe gastrointestinal symptoms such as anorexia, abdominal distension, nausea, and vomiting.

There are four main categories of liver failure:

1. Acute liver failure

He had a rapid onset, and within 2 weeks of onset, hepatic failure syndrome characterized by hepatic encephalopathy above grade II appeared.

2. Subacute liver failure

The onset is rapid, and liver failure syndrome appears within 15 days to 26 weeks of onset.

3. Acute chronic liver failure

Acute liver function decompensation based on chronic liver disease.

4. Chronic liver failure

On the basis of chronic liver disease and cirrhosis, liver function progressively declines, leading to chronic liver function decompensation with ascites or portal hypertension, coagulation dysfunction and hepatic encephalopathy as the main manifestations.

Poor efficacy and high mortality

The treatment of liver failure is mainly divided into three aspects: comprehensive medical treatment, artificial liver treatment and liver transplantation, and the overall prognosis is poor. Acute liver failure has poor medical treatment effect and high mortality, so liver transplantation should be performed early. Subacute liver failure, chronic acute liver failure, and chronic liver failure have a longer course. On the basis of medical treatment, artificial liver plasma exchange treatment can be added according to the condition to buy time for the recovery of liver function and liver transplantation. If the condition gradually recovers , Can avoid liver transplantation. If the liver function can’t be restored, liver transplantation still needs to be considered.


1. Comprehensive medical treatment

The medical treatment of liver failure still lacks specific drugs and methods. In principle, early diagnosis and early treatment are emphasized, corresponding comprehensive treatment measures are taken for different causes, and various complications are actively prevented.

2. Artificial liver treatment

Artificial liver is a temporary alternative treatment method. It refers to replacing the diseased liver to remove some harmful substances from the body through mechanical, physical, chemical or biological devices outside the body, while supplementing some essential substances to improve the internal environment, which can help the patient’s liver cells Regeneration and restoration of liver function create conditions, or create more favorable conditions for liver transplantation, but not all patients with liver failure are suitable for artificial liver treatment.

3. Liver transplantation

If the patient’s liver function still cannot be recovered after the above treatment, and the condition continues to deteriorate, he needs to consider liver transplantation as soon as possible.

 


Everyone should pay attention to avoid liver failure


Liver failure is a serious condition, difficult to treat, time-consuming, labor-intensive, and expensive, which will bring great life threats and heavy economic burdens to patients. In daily life, patients with liver disease should avoid secondary damage to the liver. They should quit smoking, quit drinking, live a regular life, stay up late, and not be too tired; try to avoid using drugs that damage the liver; take antiviral drugs according to the doctor’s instructions. Decrease and stop medication at will. Women with chronic liver disease should pay more attention to regular checkups during pregnancy and during pregnancy, and seek medical treatment immediately if abnormal liver function is found.

For ordinary people, regular physical examinations, hepatitis B vaccine injections, healthy living, avoiding obesity and fatty liver, avoiding alcoholism, unclean diet, overwork, etc., help to stay away from liver damage and liver failure. Patients with chronic liver disease should be rechecked regularly, and liver ultrasound and liver elasticity should be done. Once the liver function is found to be repeatedly abnormal or the trend of liver fibrosis, it should be treated in time. Chronic hepatitis B or C patients should regularly review the number of hepatitis B virus or hepatitis C virus. Once they meet the indications for antiviral therapy, they must actively standardize treatment.

Liver failure is a difficult point in the treatment of liver disease, and there is currently no specific treatment method. However, umbilical cord mesenchymal stem cells have the potential of sub-totipotent differentiation and are safe and reliable. The technique of vein transplantation can treat liver failure.

Umbilical cord mesenchymal stem cells refer to the mesenchymal stem cells that exist in the umbilical cord. This kind of “super-powerful” stem cells have sub-totipotent differentiation potential and can differentiate and regenerate into organs, liver, kidney, lung, pancreas, nerves, bones, etc. A variety of tissue cells such as muscles cover almost all tissue cells of the human body.

In order to prove that these “traits” will bring hope to patients with liver failure, patients with liver failure treated by intravenous transplantation of umbilical cord mesenchymal stem cells have obvious liver regeneration and liver failure has improved. It has also been confirmed that intravenous transplantation of umbilical cord mesenchymal stem cells is indeed safe and effective, and that umbilical cord mesenchymal stem cells are directly involved in the regeneration of patients’ liver cells.

Advantages of stem cell transplantation:

1. Less pain;

2. Mesenchymal stem cell transplantation has a short course of disease, and it only takes a short time to complete the complete treatment process of stem cell collection, culture, purification and infusion into the patient;

3. Low cost;

4. The curative effect is good, and the symptoms such as muscle weakness and skin hardening can be obviously improved in a short time;

5. It is not easy to cause infection.

 

(sourceinternet, reference only)


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